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LSG1 large 60S subunit nuclear export GTPase 1 [ Homo sapiens (human) ]

Gene ID: 55341, updated on 22-Aug-2020

Summary

Official Symbol
LSG1provided by HGNC
Official Full Name
large 60S subunit nuclear export GTPase 1provided by HGNC
Primary source
HGNC:HGNC:25652
See related
Ensembl:ENSG00000041802 MIM:610780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 9.7), thyroid (RPKM 9.6) and 25 other tissues See more
Orthologs

Genomic context

See LSG1 in Genome Data Viewer
Location:
3q29
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (194640788..194672191, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194361517..194393206, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TMEM44 antisense RNA 1 Neighboring gene uncharacterized LOC105374291 Neighboring gene transmembrane protein 44 Neighboring gene uncharacterized LOC105374292 Neighboring gene family with sequence similarity 43 member A Neighboring gene long intergenic non-protein coding RNA 1968 Neighboring gene Sharpr-MPRA regulatory region 10974

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11301, FLJ27294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
nuclear export IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
large subunit GTPase 1 homolog
Names
hLsg1
NP_060855.2
XP_016862285.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018385.3NP_060855.2  large subunit GTPase 1 homolog

    See identical proteins and their annotated locations for NP_060855.2

    Status: REVIEWED

    Source sequence(s)
    AC046143, AW748476, BC040119, BC068500, BQ009975, DA414880
    Consensus CDS
    CCDS33922.1
    UniProtKB/Swiss-Prot
    Q9H089
    Related
    ENSP00000265245.5, ENST00000265245.10
    Conserved Domains (3) summary
    cd01857
    Location:163444
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:151554
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    cl21455
    Location:366404
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    194640788..194672191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006796.1XP_016862285.1  large subunit GTPase 1 homolog isoform X1

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