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GIMAP5 GTPase, IMAP family member 5 [ Homo sapiens (human) ]

Gene ID: 55340, updated on 7-Apr-2025

Summary

Official Symbol
GIMAP5provided by HGNC
Official Full Name
GTPase, IMAP family member 5provided by HGNC
Primary source
HGNC:HGNC:18005
See related
Ensembl:ENSG00000196329 MIM:608086; AllianceGenome:HGNC:18005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAN4; IAN5; IROD; IAN-5; IMAP3; NCPH2; HIMAP3; IAN4L1
Summary
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]
Expression
Broad expression in lymph node (RPKM 61.1), spleen (RPKM 41.6) and 21 other tissues See more
Orthologs
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Genomic context

See GIMAP5 in Genome Data Viewer
Location:
7q36.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150737418..150743646)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151910326..151916554)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150434506..150440734)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26841 Neighboring gene GTPase, IMAP family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150403727-150404226 Neighboring gene GIMAP1-GIMAP5 readthrough Neighboring gene GTPase, IMAP family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:150432641-150433627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26843 Neighboring gene GTPase, IMAP family member 3 pseudogene Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GTPase IMAP family member 5
Names
immune associated nucleotide 4 like 1
immune-associated nucleotide-binding protein 5
immunity associated protein 3
immunity-associated nucleotide 5 protein
inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018384.5NP_060854.2  GTPase IMAP family member 5

    See identical proteins and their annotated locations for NP_060854.2

    Status: REVIEWED

    Source sequence(s)
    AC006479, CA431916
    Consensus CDS
    CCDS5907.1
    UniProtKB/Swiss-Prot
    D3DWZ5, Q6IA75, Q96F15, Q96NE4, Q9NUK9
    UniProtKB/TrEMBL
    A0A090N8P9, A0A0J9YW72, B4DNE2
    Related
    ENSP00000351473.3, ENST00000358647.5
    Conserved Domains (1) summary
    pfam04548
    Location:28228
    AIG1; AIG1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150737418..150743646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151910326..151916554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)