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GIMAP5 GTPase, IMAP family member 5 [ Homo sapiens (human) ]

Gene ID: 55340, updated on 7-Jun-2020

Summary

Official Symbol
GIMAP5provided by HGNC
Official Full Name
GTPase, IMAP family member 5provided by HGNC
Primary source
HGNC:HGNC:18005
See related
Ensembl:ENSG00000196329 MIM:608086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAN4; IAN5; IROD; IAN-5; IMAP3; HIMAP3; IAN4L1
Summary
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]
Expression
Broad expression in lymph node (RPKM 61.1), spleen (RPKM 41.6) and 21 other tissues See more
Orthologs

Genomic context

See GIMAP5 in Genome Data Viewer
Location:
7q36.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (150737348..150743649)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150434436..150440737)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 2 Neighboring gene GIMAP1-GIMAP5 readthrough Neighboring gene GTPase, IMAP family member 1 Neighboring gene GTPase, IMAP family member 3 pseudogene Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GTPase IMAP family member 5
Names
immune associated nucleotide 4 like 1
immune-associated nucleotide-binding protein 5
immunity associated protein 3
immunity-associated nucleotide 5 protein
inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018384.4NP_060854.2  GTPase IMAP family member 5

    See identical proteins and their annotated locations for NP_060854.2

    Status: REVIEWED

    Source sequence(s)
    AC006479, AV762634, CA431916
    Consensus CDS
    CCDS5907.1
    UniProtKB/Swiss-Prot
    Q96F15
    UniProtKB/TrEMBL
    A0A090N8P9
    Related
    ENSP00000351473.3, ENST00000358647.4
    Conserved Domains (1) summary
    cd01852
    Location:28228
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    150737348..150743649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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