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WDR33 WD repeat domain 33 [ Homo sapiens (human) ]

Gene ID: 55339, updated on 1-Jun-2020

Summary

Official Symbol
WDR33provided by HGNC
Official Full Name
WD repeat domain 33provided by HGNC
Primary source
HGNC:HGNC:25651
See related
Ensembl:ENSG00000136709 MIM:618082
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET14; WDC146
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See WDR33 in Genome Data Viewer
Location:
2q14.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (127701027..127811187, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128461808..128568761, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene myosin VIIB Neighboring gene uncharacterized LOC101927834 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene G protein-coupled receptor 17 Neighboring gene SFT2 domain containing 3 Neighboring gene RNY4 pseudogene 7 Neighboring gene RNA, U6 small nuclear 395, pseudogene Neighboring gene ZFP91 pseudogene 1 Neighboring gene RNA polymerase II subunit D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
NHGRI GWA Catalog
Genetics of coronary artery calcification among African Americans, a meta-analysis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
postreplication repair NAS
Non-traceable Author Statement
more info
PubMed 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pre-mRNA 3' end processing protein WDR33
Names
WD repeat-containing protein 33
WD repeat-containing protein WDC146
WD repeat-containing protein of 146 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006622.2NP_001006623.1  pre-mRNA 3' end processing protein WDR33 isoform 2

    See identical proteins and their annotated locations for NP_001006623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the shortest transcript. It lacks multiple 3' exons but has an alternate 3' segment, as compared to variant 1. The encoded isoform 2 has a shorter and distinct C-terminus, has only two WD repeats, and lacks the collagen-like and GPR domains, compared to isoform 1.
    Source sequence(s)
    AI039494, AK002156, BC005401, BM673679, DA768238
    Consensus CDS
    CCDS46407.1
    UniProtKB/Swiss-Prot
    Q9C0J8
    Related
    ENSP00000387186.3, ENST00000409658.7
    Conserved Domains (2) summary
    sd00039
    Location:122158
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:119205
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001006623.3NP_001006624.1  pre-mRNA 3' end processing protein WDR33 isoform 3

    See identical proteins and their annotated locations for NP_001006624.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. It encodes the shortest isoform (3), which has a shorter and distinct C-terminus, as compared to isoform 1, has only two WD repeats, and lacks the collagen-like and GPR domains.
    Source sequence(s)
    AC006011, BC068484, BU597855, DB324904
    Consensus CDS
    CCDS42746.1
    UniProtKB/Swiss-Prot
    Q9C0J8
    Related
    ENSP00000376730.1, ENST00000393006.5
    Conserved Domains (3) summary
    COG2319
    Location:104251
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:122159
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:119230
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_018383.5NP_060853.3  pre-mRNA 3' end processing protein WDR33 isoform 1

    See identical proteins and their annotated locations for NP_060853.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1) with eight WD repeats, a collagen-like domain, and a GPR (Gly, Pro and Arg)-rich domain at the N-terminal, central, and C-terminal portion, respectively.
    Source sequence(s)
    AB044749, AC006011, AL834365, BC010283, BQ896760, DA768238
    Consensus CDS
    CCDS2150.1
    UniProtKB/Swiss-Prot
    Q9C0J8
    Related
    ENSP00000325377.3, ENST00000322313.9
    Conserved Domains (5) summary
    pfam01391
    Location:730791
    Collagen; Collagen triple helix repeat (20 copies)
    COG2319
    Location:121405
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:121402
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam09606
    Location:594989
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    sd00039
    Location:122159
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    127701027..127811187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511436.1XP_011509738.1  pre-mRNA 3' end processing protein WDR33 isoform X1

    See identical proteins and their annotated locations for XP_011509738.1

    UniProtKB/Swiss-Prot
    Q9C0J8
    Conserved Domains (5) summary
    pfam01391
    Location:730791
    Collagen; Collagen triple helix repeat (20 copies)
    COG2319
    Location:121405
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:121402
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam09606
    Location:594989
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    sd00039
    Location:122159
    7WD40; WD40 repeat [structural motif]
  2. XM_005263697.3XP_005263754.1  pre-mRNA 3' end processing protein WDR33 isoform X2

    Conserved Domains (4) summary
    pfam01391
    Location:730791
    Collagen; Collagen triple helix repeat (20 copies)
    COG2319
    Location:121405
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:121402
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:122159
    7WD40; WD40 repeat [structural motif]
  3. XM_017004436.2XP_016859925.1  pre-mRNA 3' end processing protein WDR33 isoform X4

  4. XM_017004435.1XP_016859924.1  pre-mRNA 3' end processing protein WDR33 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:122159
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:119230
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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