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acvr2aa activin A receptor type 2Aa [ Danio rerio (zebrafish) ]

Gene ID: 553359, updated on 9-Sep-2025
Official Symbol
acvr2aaprovided by ZNC
Official Full Name
activin A receptor type 2Aaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-227
See related
Ensembl:ENSDARG00000011188 AllianceGenome:ZFIN:ZDB-GENE-980526-227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
acvr2; actr2a; acvr2a; wu:fa02e10
Summary
Predicted to enable activin binding activity and activin receptor activity. Acts upstream of or within several processes, including cartilage development; dorsal/ventral pattern formation; and neural crest cell migration. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blastoderm; blastomere; gut; oral region; and ovarian follicle. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See acvr2aa in Genome Data Viewer
Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 9 NC_133184.1 (27005851..27069279, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 9 NC_007120.7 (25380790..25444213, complement)

Chromosome 9 - NC_133184.1Genomic Context describing neighboring genes Neighboring gene integral membrane protein 2Bb Neighboring gene enhancer of polycomb 2 Neighboring gene uncharacterized LOC141376131 Neighboring gene uncharacterized LOC141376133 Neighboring gene uncharacterized LOC141376134

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Epidermal growth factor and TGFalpha promote zebrafish oocyte maturation in vitro: potential role of the ovarian activin regulatory system. Pang Y, et al. Endocrinology, 2002 Jan. PMID 11751590
  2. Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1(R206H) -Specific Human Cellular and Zebrafish Models. Wentworth KL, et al. J Bone Miner Res, 2022 Nov. PMID 36153796, Free PMC Article
  3. Cloning of a second form of activin-betaA cDNA and regulation of activin-betaA subunits and activin type II receptor mRNA expression by gonadotropin in the zebrafish ovary. DiMuccio T, et al. Gen Comp Endocrinol, 2005 Sep 15. PMID 15925369
  4. Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Albertson RC, et al. Dev Dyn, 2005 Aug. PMID 15977175
  5. Dual specificity of activin type II receptor ActRIIb in dorso-ventral patterning during zebrafish embryogenesis. Nagaso H, et al. Dev Growth Differ, 1999 Apr. PMID 10223708

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhbaa signaled through Acvr2a over Acvr2b during zebrafish cardiac regeneration.
    Title: Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair.
  2. Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.
    Title: Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables activin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in developmental process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
activin receptor type-2A
Names
activin A receptor, type IIAa
activin receptor IIa
etID22865.9
NP_001103748.2
XP_005167618.1
XP_021334336.1
XP_021334337.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110278.2 → NP_001103748.2  activin receptor type-2A precursor

    Status: VALIDATED

    Source sequence(s)
    EH574532, JBMGRA010000009
    UniProtKB/TrEMBL
    A0A8M1NG95, F1QG01
    Related
    ENSDARP00000024124.8, ENSDART00000002428.10
    Conserved Domains (3) summary
    smart00220
    Location:201 → 473
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14141
    Location:197 → 486
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:60 → 119
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133184.1 Reference GRCz12tu Primary Assembly

    Range
    27005851..27069279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478662.3 → XP_021334337.1  activin receptor type-2A isoform X3

    UniProtKB/TrEMBL
    A0A8M9PS26
    Conserved Domains (2) summary
    cd14141
    Location:205 → 494
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:43 → 115
    Activin_recp; Activin types I and II receptor domain

  2. XM_005167561.6 → XP_005167618.1  activin receptor type-2A isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFL8
    Related
    ENSDARP00000111494.2
    Conserved Domains (3) summary
    smart00220
    Location:217 → 489
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14141
    Location:213 → 502
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:60 → 119
    Activin_recp; Activin types I and II receptor domain

  3. XM_021478661.3 → XP_021334336.1  activin receptor type-2A isoform X1

    UniProtKB/TrEMBL
    A0A8M9QFD6
    Related
    ENSDARP00000096265.5
    Conserved Domains (2) summary
    cd14141
    Location:221 → 510
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:43 → 115
    Activin_recp; Activin types I and II receptor domain
Nucleotide Protein Strain
Heading Accession and Version

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