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polr2a RNA polymerase II subunit A [ Danio rerio (zebrafish) ]

Gene ID: 553347, updated on 14-Jul-2025
Official Symbol
polr2aprovided by ZNC
Official Full Name
RNA polymerase II subunit Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041008-78
See related
Ensembl:ENSDARG00000099966 AllianceGenome:ZFIN:ZDB-GENE-041008-78
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7136071
Summary
Predicted to enable nucleic acid binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in mRNA transcription by RNA polymerase II. Predicted to be located in chromosome; cytoplasm; and nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is expressed in blastomere. Orthologous to human POLR2A (RNA polymerase II subunit A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See polr2a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 12 NC_133187.1 (24299045..24312211)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 12 NC_007123.7 (22560131..22573297)

Chromosome 12 - NC_133187.1Genomic Context describing neighboring genes Neighboring gene sex hormone-binding globulin Neighboring gene uncharacterized LOC141376801 Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene capping protein (actin filament), gelsolin-like b Neighboring gene si:dkey-219e21.2

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
DNA-directed RNA polymerase II subunit RPB1
Names
polymerase (RNA) II (DNA directed) polypeptide A
XP_005156282.1

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133187.1 Reference GRCz12tu Primary Assembly

    Range
    24299045..24312211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156225.5XP_005156282.1  DNA-directed RNA polymerase II subunit RPB1

    UniProtKB/TrEMBL
    A0A0R4IMS9, A0A8M2B2W1
    Related
    ENSDARP00000135038.1, ENSDART00000172066.2
    Conserved Domains (8) summary
    cd02584
    Location:10551473
    RNAP_II_Rpb1_C; Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
    smart01104
    Location:15061611
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    PRK08566
    Location:16892
    PRK08566; DNA-directed RNA polymerase subunit A'; Validated
    cd02733
    Location:17873
    RNAP_II_RPB1_N; Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain
    pfam04992
    Location:8931076
    RNA_pol_Rpb1_6; RNA polymerase Rpb1, domain 6
    pfam04998
    Location:8271425
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
    pfam11786
    Location:14941571
    Aft1_HRA; Aft1 HRA domain
    cl23782
    Location:18691948
    RCR; Chitin synthesis regulation, resistance to Congo red