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PPP3CC protein phosphatase 3 catalytic subunit gamma [ Homo sapiens (human) ]

Gene ID: 5533, updated on 4-Oct-2020

Summary

Official Symbol
PPP3CCprovided by HGNC
Official Full Name
protein phosphatase 3 catalytic subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:9316
See related
Ensembl:ENSG00000120910 MIM:114107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNA3; CALNA3; PP2Bgamma
Summary
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Broad expression in testis (RPKM 12.3), lymph node (RPKM 5.3) and 24 other tissues See more
Orthologs

Genomic context

See PPP3CC in Genome Data Viewer
Location:
8p21.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22441053..22541466)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22298483..22398657)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 14 Neighboring gene ribosomal protein L21 pseudogene 77 Neighboring gene RNA, U6 small nuclear 336, pseudogene Neighboring gene BTF3 pseudogene 3 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene PDZ and LIM domain 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host determinants of HIV-1 control in African Americans.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
brain development IEA
Inferred from Electronic Annotation
more info
 
calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Names
CAM-PRP catalytic subunit
calcineurin, testis-specific catalytic subunit
protein phosphatase 3, catalytic subunit, gamma isozyme
NP_001230903.1
NP_001230904.1
NP_005596.2
XP_016869100.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243974.2NP_001230903.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1

    See identical proteins and their annotated locations for NP_001230903.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC037459, AK055013, AK299415, AY007249
    Consensus CDS
    CCDS59093.1
    UniProtKB/Swiss-Prot
    P48454
    Related
    ENSP00000380878.3, ENST00000397775.7
    Conserved Domains (2) summary
    smart00156
    Location:54325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  2. NM_001243975.2NP_001230904.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3

    See identical proteins and their annotated locations for NP_001230904.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AK055013, AK299415, AY007249, S46622
    Consensus CDS
    CCDS59094.1
    UniProtKB/Swiss-Prot
    P48454
    Related
    ENSP00000289963.8, ENST00000289963.12
    Conserved Domains (2) summary
    smart00156
    Location:54325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  3. NM_005605.5NP_005596.2  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

    See identical proteins and their annotated locations for NP_005596.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK055013, AY007249, BC004864
    Consensus CDS
    CCDS34859.1
    UniProtKB/Swiss-Prot
    P48454
    Related
    ENSP00000240139.5, ENST00000240139.9
    Conserved Domains (1) summary
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22441053..22541466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013611.2XP_016869100.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

RNA

  1. XR_001745557.2 RNA Sequence

  2. XR_001745558.2 RNA Sequence

  3. XR_001745556.2 RNA Sequence

  4. XR_001745554.2 RNA Sequence

  5. XR_001745553.2 RNA Sequence

  6. XR_001745555.2 RNA Sequence

  7. XR_001745559.2 RNA Sequence

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