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RNLS renalase, FAD dependent amine oxidase [ Homo sapiens (human) ]

Gene ID: 55328, updated on 23-Nov-2021

Summary

Official Symbol
RNLSprovided by HGNC
Official Full Name
renalase, FAD dependent amine oxidaseprovided by HGNC
Primary source
HGNC:HGNC:25641
See related
Ensembl:ENSG00000184719 MIM:609360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf59; RENALASE
Summary
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See RNLS in Genome Data Viewer
Location:
10q23.31
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (88176052..88584480, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90033619..90343075, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378415 Neighboring gene uncharacterized LOC105378416 Neighboring gene uncharacterized LOC101929727 Neighboring gene vomeronasal 1 receptor 55 pseudogene Neighboring gene lipase family member J Neighboring gene ribosomal protein L7 pseudogene 34 Neighboring gene lipase F, gastric type

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11218

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADH binding IDA
Inferred from Direct Assay
more info
PubMed 
enables epinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables monoamine oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidoreductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of heart rate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to epinephrine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to salt IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
renalase
Names
MAO-C
alpha-NAD(P)H oxidase/anomerase
monoamine oxidase-C
NP_001026879.2
NP_060833.1
XP_005270003.1
XP_005270004.1
XP_005270005.1
XP_005270006.1
XP_005270007.1
XP_011538226.1
XP_011538229.1
XP_016871869.1
XP_016871870.1
XP_016871871.1
XP_016871872.1
XP_016871873.1
XP_016871874.1
XP_024303831.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031709.3NP_001026879.2  renalase isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026879.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA854849, AL353149, BC005364, BM978857, BP332262
    Consensus CDS
    CCDS31239.1
    UniProtKB/Swiss-Prot
    Q5VYX0
    Related
    ENSP00000332530.4, ENST00000331772.9
    Conserved Domains (3) summary
    COG3380
    Location:1342
    COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_018363.4NP_060833.1  renalase isoform 2 precursor

    See identical proteins and their annotated locations for NP_060833.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK002080, AL353149, BP332262
    Consensus CDS
    CCDS7388.1
    UniProtKB/Swiss-Prot
    Q5VYX0
    Related
    ENSP00000361015.3, ENST00000371947.7
    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    88176052..88584480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016382.2XP_016871871.1  renalase isoform X8

    UniProtKB/TrEMBL
    B4DJW3
    Conserved Domains (1) summary
    pfam13450
    Location:640
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. XM_011539924.3XP_011538226.1  renalase isoform X1

    See identical proteins and their annotated locations for XP_011538226.1

    UniProtKB/Swiss-Prot
    Q5VYX0
    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_017016380.2XP_016871869.1  renalase isoform X1

    UniProtKB/Swiss-Prot
    Q5VYX0
    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_005269950.4XP_005270007.1  renalase isoform X8

    See identical proteins and their annotated locations for XP_005270007.1

    UniProtKB/TrEMBL
    B4DJW3
    Conserved Domains (1) summary
    pfam13450
    Location:640
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  5. XM_017016384.2XP_016871873.1  renalase isoform X11

  6. XM_005269948.3XP_005270005.1  renalase isoform X6

    Conserved Domains (2) summary
    COG3380
    Location:41259
    COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]
    pfam13450
    Location:640
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  7. XM_024448063.1XP_024303831.1  renalase isoform X9

    Conserved Domains (2) summary
    pfam13450
    Location:640
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl27536
    Location:41208
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
  8. XM_005269947.2XP_005270004.1  renalase isoform X5

    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  9. XM_005269946.2XP_005270003.1  renalase isoform X2

    See identical proteins and their annotated locations for XP_005270003.1

    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  10. XM_017016385.1XP_016871874.1  renalase isoform X12

  11. XM_011539927.3XP_011538229.1  renalase isoform X3

    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  12. XM_017016381.2XP_016871870.1  renalase isoform X4

  13. XM_005269949.5XP_005270006.1  renalase isoform X7

    Conserved Domains (2) summary
    pfam13450
    Location:680
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:109226
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  14. XM_017016383.2XP_016871872.1  renalase isoform X10

    Related
    ENSP00000387577.2, ENST00000437752.2

RNA

  1. XR_001747122.2 RNA Sequence

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