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LIN7C lin-7 homolog C, crumbs cell polarity complex component [ Homo sapiens (human) ]

Gene ID: 55327, updated on 6-Nov-2022

Summary

Official Symbol
LIN7Cprovided by HGNC
Official Full Name
lin-7 homolog C, crumbs cell polarity complex componentprovided by HGNC
Primary source
HGNC:HGNC:17789
See related
Ensembl:ENSG00000148943 MIM:612332; AllianceGenome:HGNC:17789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
Summary
Enables L27 domain binding activity and cytoskeletal protein binding activity. Involved in morphogenesis of an epithelial sheet. Located in cell-cell junction; cytoplasm; and plasma membrane. Part of MPP7-DLG1-LIN7 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 9.8), liver (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See LIN7C in Genome Data Viewer
Location:
11p14.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (27494418..27506769, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (27634869..27647239, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27515965..27528316, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing G protein-coupled receptor 4 Neighboring gene LGR4 antisense RNA 1 Neighboring gene ribosomal protein L37a pseudogene 7 Neighboring gene BDNF antisense RNA Neighboring gene RNA, 5S ribosomal pseudogene 339 Neighboring gene microRNA 8087

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of lin-7 homolog C (C. elegans, LIN7C) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11215

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L27 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L27 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of MPP7-DLG1-LIN7 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MPP7-DLG1-LIN7 complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein lin-7 homolog C
Names
LIN-7 protein 3
mammalian lin-seven protein 3
veli-3
vertebrate lin-7 homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018362.4NP_060832.1  protein lin-7 homolog C

    See identical proteins and their annotated locations for NP_060832.1

    Status: VALIDATED

    Source sequence(s)
    AK025540, BC039459, BC053907, DA231006
    Consensus CDS
    CCDS7864.1
    UniProtKB/Swiss-Prot
    Q9NUP9
    Related
    ENSP00000278193.2, ENST00000278193.7
    Conserved Domains (2) summary
    cd00992
    Location:91172
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:1466
    L27; L27 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    27494418..27506769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    27634869..27647239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)