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ABCF3 ATP binding cassette subfamily F member 3 [ Homo sapiens (human) ]

Gene ID: 55324, updated on 22-Aug-2020

Summary

Official Symbol
ABCF3provided by HGNC
Official Full Name
ATP binding cassette subfamily F member 3provided by HGNC
Primary source
HGNC:HGNC:72
See related
Ensembl:ENSG00000161204 MIM:618967
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EST201864
Summary
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. The protein encoded by this gene displays antiviral effect against flaviviruses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in adrenal (RPKM 33.9), testis (RPKM 16.2) and 25 other tissues See more
Orthologs

Genomic context

See ABCF3 in Genome Data Viewer
Location:
3q27.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (184186075..184194012)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183903863..183911795)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 3 Neighboring gene adaptor related protein complex 2 subunit mu 1 Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene EEF1AKMT4-ECE2 readthrough Neighboring gene microRNA 1224 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene ALG3 alpha-1,3- mannosyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A mega-analysis of genome-wide association studies for major depressive disorder.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11198

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family F member 3
Names
ATP-binding cassette, sub-family F (GCN20), member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054899.1 RefSeqGene

    Range
    5001..12933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351298.1NP_001338227.1  ATP-binding cassette sub-family F member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC131235
    Consensus CDS
    CCDS87173.1
    Related
    ENSP00000292808.4, ENST00000292808.5
    Conserved Domains (1) summary
    cl26602
    Location:6694
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
  2. NM_001351299.2NP_001338228.1  ATP-binding cassette sub-family F member 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC131235
    Conserved Domains (1) summary
    COG0488
    Location:42459
    Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
  3. NM_001351300.2NP_001338229.1  ATP-binding cassette sub-family F member 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC131235
    Conserved Domains (1) summary
    cl26602
    Location:9479
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
  4. NM_018358.2NP_060828.2  ATP-binding cassette sub-family F member 3 isoform 1

    See identical proteins and their annotated locations for NP_060828.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK002060, BC035652, DB079392, DC318082
    Consensus CDS
    CCDS3254.1
    UniProtKB/Swiss-Prot
    Q9NUQ8
    UniProtKB/TrEMBL
    A0A0S2Z5L1
    Related
    ENSP00000411471.2, ENST00000429586.6
    Conserved Domains (1) summary
    cl26602
    Location:6700
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    184186075..184194012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453625.1XP_024309393.1  ATP-binding cassette sub-family F member 3 isoform X1

    Conserved Domains (1) summary
    cl26602
    Location:9479
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
  2. XM_024453624.1XP_024309392.1  ATP-binding cassette sub-family F member 3 isoform X1

    Related
    ENST00000473311.5
    Conserved Domains (1) summary
    cl26602
    Location:9479
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
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