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C5orf22 chromosome 5 open reading frame 22 [ Homo sapiens (human) ]

Gene ID: 55322, updated on 18-Aug-2020

Summary

Official Symbol
C5orf22provided by HGNC
Official Full Name
chromosome 5 open reading frame 22provided by HGNC
Primary source
HGNC:HGNC:25639
See related
Ensembl:ENSG00000082213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 6.1), colon (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See C5orf22 in Genome Data Viewer
Location:
5p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (31532275..31555053)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (31532373..31555165)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cadherin 6 Neighboring gene double homeobox 4 like 51 (pseudogene) Neighboring gene drosha ribonuclease III Neighboring gene RNA, U6 small nuclear 363, pseudogene Neighboring gene PDZ domain containing 2 Neighboring gene RNA, U6 small nuclear 358, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11193, FLJ23805, MGC33010, DKFZp667N066

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018356.3NP_060826.2  UPF0489 protein C5orf22

    See identical proteins and their annotated locations for NP_060826.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AI300780, AK074385, AV710784, BC021215, BM683466, DA783320
    Consensus CDS
    CCDS3895.1
    UniProtKB/Swiss-Prot
    Q49AR2
    UniProtKB/TrEMBL
    A0A024RE14
    Related
    ENSP00000326879.9, ENST00000325366.14
    Conserved Domains (1) summary
    pfam12640
    Location:19176
    UPF0489; UPF0489 domain

RNA

  1. NR_134298.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate internal splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022417, BC032845
    Related
    ENST00000510659.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    31532275..31555053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009612.2XP_016865101.1  UPF0489 protein C5orf22 isoform X6

  2. XM_017009611.2XP_016865100.1  UPF0489 protein C5orf22 isoform X6

  3. XM_017009607.1XP_016865096.1  UPF0489 protein C5orf22 isoform X1

  4. XM_017009610.1XP_016865099.1  UPF0489 protein C5orf22 isoform X6

  5. XM_017009616.1XP_016865105.1  UPF0489 protein C5orf22 isoform X7

    UniProtKB/Swiss-Prot
    Q49AR2
    UniProtKB/TrEMBL
    A0A024RE20
    Conserved Domains (1) summary
    pfam10098
    Location:2371
    DUF2336; Uncharacterized protein conserved in bacteria (DUF2336)
  6. XM_011514062.3XP_011512364.1  UPF0489 protein C5orf22 isoform X3

    Conserved Domains (1) summary
    pfam12640
    Location:19207
    UPF0489; UPF0489 domain
  7. XM_017009614.1XP_016865103.1  UPF0489 protein C5orf22 isoform X7

    UniProtKB/Swiss-Prot
    Q49AR2
    UniProtKB/TrEMBL
    A0A024RE20
    Conserved Domains (1) summary
    pfam10098
    Location:2371
    DUF2336; Uncharacterized protein conserved in bacteria (DUF2336)
  8. XM_017009615.1XP_016865104.1  UPF0489 protein C5orf22 isoform X7

    UniProtKB/Swiss-Prot
    Q49AR2
    UniProtKB/TrEMBL
    A0A024RE20
    Conserved Domains (1) summary
    pfam10098
    Location:2371
    DUF2336; Uncharacterized protein conserved in bacteria (DUF2336)
  9. XM_006714480.3XP_006714543.1  UPF0489 protein C5orf22 isoform X7

    See identical proteins and their annotated locations for XP_006714543.1

    UniProtKB/Swiss-Prot
    Q49AR2
    UniProtKB/TrEMBL
    A0A024RE20
    Conserved Domains (1) summary
    pfam10098
    Location:2371
    DUF2336; Uncharacterized protein conserved in bacteria (DUF2336)
  10. XM_017009608.2XP_016865097.1  UPF0489 protein C5orf22 isoform X2

  11. XM_017009609.1XP_016865098.1  UPF0489 protein C5orf22 isoform X4

  12. XM_006714479.2XP_006714542.1  UPF0489 protein C5orf22 isoform X5

    Conserved Domains (1) summary
    pfam12640
    Location:192
    UPF0489; UPF0489 domain
  13. XM_017009613.2XP_016865102.1  UPF0489 protein C5orf22 isoform X7

    UniProtKB/Swiss-Prot
    Q49AR2
    UniProtKB/TrEMBL
    A0A024RE20
    Conserved Domains (1) summary
    pfam10098
    Location:2371
    DUF2336; Uncharacterized protein conserved in bacteria (DUF2336)
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