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C5orf22 chromosome 5 open reading frame 22 [ Homo sapiens (human) ]

Gene ID: 55322, updated on 5-Mar-2024

Summary

Official Symbol
C5orf22provided by HGNC
Official Full Name
chromosome 5 open reading frame 22provided by HGNC
Primary source
HGNC:HGNC:25639
See related
Ensembl:ENSG00000082213 AllianceGenome:HGNC:25639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 6.1), colon (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See C5orf22 in Genome Data Viewer
Location:
5p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (31532301..31555053)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (31646012..31668762)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (31532408..31555160)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cadherin 6 Neighboring gene double homeobox 4 like 51 (pseudogene) Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:31342590-31343789 Neighboring gene NANOG hESC enhancer GRCh37_chr5:31427117-31427643 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:31452968-31453512 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84469 Neighboring gene drosha ribonuclease III Neighboring gene Sharpr-MPRA regulatory region 6191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:31493720-31494220 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22432 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:31618177-31618357 Neighboring gene RNA, U6 small nuclear 363, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:31680333-31680851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:31680852-31681369 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:31716787-31717309 Neighboring gene PDZ domain containing 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:31753742-31754275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22434 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:31780232-31780511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:31798873-31799374 Neighboring gene RNA, U6 small nuclear 358, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11193, FLJ23805, MGC33010, DKFZp667N066

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018356.3NP_060826.2  UPF0489 protein C5orf22

    See identical proteins and their annotated locations for NP_060826.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AI300780, AK074385, AV710784, BC021215, BM683466, DA783320
    Consensus CDS
    CCDS3895.1
    UniProtKB/Swiss-Prot
    Q49AR2, Q8ND28, Q8WU61, Q9NUR1
    Related
    ENSP00000326879.9, ENST00000325366.14
    Conserved Domains (1) summary
    pfam12640
    Location:19176
    UPF0489; UPF0489 domain

RNA

  1. NR_134298.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate internal splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022417, BC032845
    Related
    ENST00000510659.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    31532301..31555053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009607.2XP_016865096.1  UPF0489 protein C5orf22 isoform X1

  2. XM_011514062.4XP_011512364.1  UPF0489 protein C5orf22 isoform X3

    Conserved Domains (1) summary
    pfam12640
    Location:19207
    UPF0489; UPF0489 domain
  3. XM_017009608.3XP_016865097.1  UPF0489 protein C5orf22 isoform X2

  4. XM_017009609.2XP_016865098.1  UPF0489 protein C5orf22 isoform X4

  5. XM_006714479.3XP_006714542.1  UPF0489 protein C5orf22 isoform X5

    Conserved Domains (1) summary
    pfam12640
    Location:192
    UPF0489; UPF0489 domain
  6. XM_006714480.4XP_006714543.1  UPF0489 protein C5orf22 isoform X6

    See identical proteins and their annotated locations for XP_006714543.1

    Conserved Domains (1) summary
    pfam10098
    Location:2371
    DUF2336; Uncharacterized protein conserved in bacteria (DUF2336)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    31646012..31668762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352886.1XP_054208861.1  UPF0489 protein C5orf22 isoform X1

  2. XM_054352888.1XP_054208863.1  UPF0489 protein C5orf22 isoform X3

  3. XM_054352887.1XP_054208862.1  UPF0489 protein C5orf22 isoform X2

  4. XM_054352889.1XP_054208864.1  UPF0489 protein C5orf22 isoform X4

  5. XM_054352890.1XP_054208865.1  UPF0489 protein C5orf22 isoform X5

  6. XM_054352891.1XP_054208866.1  UPF0489 protein C5orf22 isoform X6