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TMA16 translation machinery associated 16 homolog [ Homo sapiens (human) ]

Gene ID: 55319, updated on 17-Sep-2024

Summary

Official Symbol
TMA16provided by HGNC
Official Full Name
translation machinery associated 16 homologprovided by HGNC
Primary source
HGNC:HGNC:25638
See related
Ensembl:ENSG00000198498 AllianceGenome:HGNC:25638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf43
Summary
Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 10.4), endometrium (RPKM 8.9) and 25 other tissues See more
Orthologs
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Genomic context

See TMA16 in Genome Data Viewer
Location:
4q32.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (163494690..163520539)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (166842563..166868413)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (164415842..164441691)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:164336685-164337439 Neighboring gene ribosomal protein L35a pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15780 Neighboring gene uncharacterized LOC124900805 Neighboring gene CRISPRi-validated cis-regulatory element chr4.3253 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:164415733-164416635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:164461973-164462472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:164471307-164471806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:164470805-164471306 Neighboring gene transketolase like 2 Neighboring gene membrane associated ring-CH-type finger 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22103 Neighboring gene uncharacterized LOC107986325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22105 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:164614705-164615904 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:164658768-164658959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22106 Neighboring gene RN7SK pseudogene 105

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11184, FLJ52950

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables preribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ribosomal large subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
translation machinery-associated protein 16
Names
UPF0534 protein C4orf43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018352.3NP_060822.2  translation machinery-associated protein 16

    See identical proteins and their annotated locations for NP_060822.2

    Status: VALIDATED

    Source sequence(s)
    AA772718, AW518118, BC011842, BU159489, BX370094
    Consensus CDS
    CCDS43278.1
    UniProtKB/Swiss-Prot
    Q0P6E4, Q0P6J1, Q96EY4, Q9NUR7
    UniProtKB/TrEMBL
    H0Y9X1
    Related
    ENSP00000351380.5, ENST00000358572.10
    Conserved Domains (1) summary
    pfam11176
    Location:13163
    Tma16; Translation machinery-associated protein 16

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    163494690..163520539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    166842563..166868413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)