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dnmt3ab DNA (cytosine-5-)-methyltransferase 3 alpha b [ Danio rerio (zebrafish) ]

Gene ID: 553189, updated on 17-Nov-2020

Summary

Official Symbol
dnmt3abprovided by ZNC
Official Full Name
DNA (cytosine-5-)-methyltransferase 3 alpha bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050314-3
See related
Ensembl:ENSDARG00000015566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dnmt; dnmt3; dnmt6; dnmt3a1
Orthologs

Genomic context

See dnmt3ab in Genome Data Viewer
Location:
chromosome: 17
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (36937808..37054963, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (36993285..37107437, complement)
103 previous assembly Zv9 (GCF_000002035.4) 17 NC_007128.5 (37105330..37222462, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein, RP/EB family, member 3a Neighboring gene dihydropyrimidinase like 5a Neighboring gene dystrobrevin, beta b Neighboring gene ASXL transcriptional regulator 2

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
DNA (cytosine-5-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA methylation IEA
Inferred from Electronic Annotation
more info
 
methylation IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA (cytosine-5)-methyltransferase 3A
Names
DNA (cytosine-5-)-methyltransferase 6
NP_001018150.1
NP_001315096.1
XP_005158902.1
XP_009291474.1
XP_009291475.1
XP_021322836.1
XP_021322837.1
XP_021322838.1
XP_021322839.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018140.2NP_001018150.1  DNA (cytosine-5)-methyltransferase 3A isoform 2

    See identical proteins and their annotated locations for NP_001018150.1

    Status: VALIDATED

    Source sequence(s)
    BX571720
    UniProtKB/TrEMBL
    Q588C4
    Related
    ENSDARP00000108609.2, ENSDART00000126823.3
    Conserved Domains (3) summary
    cd05835
    Location:112198
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:449612
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11729
    Location:304431
    ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
  2. NM_001328167.1NP_001315096.1  DNA (cytosine-5)-methyltransferase 3A isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX571720, CR388401
    UniProtKB/TrEMBL
    F1R1K5
    Related
    ENSDARP00000126446.1, ENSDART00000151921.3
    Conserved Domains (3) summary
    cd05835
    Location:359445
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:696859
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11729
    Location:551678
    ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    36937808..37054963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467162.1XP_021322837.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

    Conserved Domains (3) summary
    cd05835
    Location:364450
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:701864
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11729
    Location:556683
    ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
  2. XM_005158845.4XP_005158902.1  DNA (cytosine-5)-methyltransferase 3A isoform X5

    See identical proteins and their annotated locations for XP_005158902.1

    UniProtKB/TrEMBL
    B3DGZ8
    Related
    ENSDARP00000151802.1, ENSDART00000187180.1
    Conserved Domains (3) summary
    cd05835
    Location:112198
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:449609
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11729
    Location:304431
    ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
  3. XM_021467161.1XP_021322836.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

    Conserved Domains (3) summary
    cd05835
    Location:364450
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:701864
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11729
    Location:556683
    ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
  4. XM_021467163.1XP_021322838.1  DNA (cytosine-5)-methyltransferase 3A isoform X2

    Conserved Domains (3) summary
    cd05835
    Location:364450
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:701861
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11729
    Location:556683
    ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
  5. XM_009293199.3XP_009291474.1  DNA (cytosine-5)-methyltransferase 3A isoform X3

    Conserved Domains (3) summary
    cd05835
    Location:310396
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:647810
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11729
    Location:502629
    ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
  6. XM_009293200.3XP_009291475.1  DNA (cytosine-5)-methyltransferase 3A isoform X4

    See identical proteins and their annotated locations for XP_009291475.1

    UniProtKB/TrEMBL
    Q588C4
    Conserved Domains (3) summary
    cd05835
    Location:112198
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:449612
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11729
    Location:304431
    ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
  7. XM_021467164.1XP_021322839.1  DNA (cytosine-5)-methyltransferase 3A isoform X6

    Conserved Domains (2) summary
    cd05835
    Location:364450
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cl28890
    Location:556585
    FYVE_like_SF; FYVE domain like superfamily
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