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PRR5-ARHGAP8 PRR5-ARHGAP8 readthrough [ Homo sapiens (human) ]

Gene ID: 553158, updated on 13-Aug-2022

Summary

Official Symbol
PRR5-ARHGAP8provided by HGNC
Official Full Name
PRR5-ARHGAP8 readthroughprovided by HGNC
Primary source
HGNC:HGNC:34512
See related
Ensembl:ENSG00000248405 AllianceGenome:HGNC:34512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The PRR5-ARHGAP8 mRNA is an infrequent but naturally occurring read-through transcript of the neighboring proline rich 5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8) genes. The resulting fusion protein contains sequence identity with each individual gene product, and it includes domains characteristic of a RhoGAP protein. The significance of this read-through transcript and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2010]
Expression
Broad expression in kidney (RPKM 5.8), spleen (RPKM 4.9) and 21 other tissues See more
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Genomic context

See PRR5-ARHGAP8 in Genome Data Viewer
Location:
22q13.31
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (44702204..44862784)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (45185955..45346305)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (45098084..45258664)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905132 Neighboring gene acidic nuclear phosphoprotein 32 family member B pseudogene 2 Neighboring gene proline rich 5 Neighboring gene Sharpr-MPRA regulatory region 7347 Neighboring gene Rho GTPase activating protein 8 Neighboring gene uncharacterized LOC105373062 Neighboring gene uncharacterized LOC124905133 Neighboring gene PHD finger protein 21B Neighboring gene ribosomal protein L6 pseudogene 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Bipolar disorder with comorbid binge eating history: A genome-wide association study implicates APOB.
EBI GWAS Catalog
Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
EBI GWAS Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
PRR5-ARHGAP8 fusion protein
Names
PRR5-ARHGAP8 fusion

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046967.1 RefSeqGene

    Range
    5001..165587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181334.6NP_851851.3  PRR5-ARHGAP8 fusion protein

    Status: REVIEWED

    Source sequence(s)
    AF195968, BX335168, Z83838, Z98743
    UniProtKB/TrEMBL
    A6NDT3, B1AHC3
    Related
    ENSP00000354732.5, ENST00000361473.9
    Conserved Domains (2) summary
    cd00170
    Location:143288
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl02570
    Location:322512
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    44702204..44862784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    45185955..45346305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)