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CPPED1 calcineurin like phosphoesterase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55313, updated on 18-Aug-2020

Summary

Official Symbol
CPPED1provided by HGNC
Official Full Name
calcineurin like phosphoesterase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25632
See related
Ensembl:ENSG00000103381 MIM:615603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSTP1
Expression
Ubiquitous expression in spleen (RPKM 8.6), kidney (RPKM 8.5) and 24 other tissues See more
Orthologs

Genomic context

See CPPED1 in Genome Data Viewer
Location:
16p13.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (12659799..12803887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (12753656..12897744, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr16.1337 Neighboring gene uncharacterized LOC105371088 Neighboring gene Sharpr-MPRA regulatory region 10358 Neighboring gene uncharacterized LOC105371090 Neighboring gene uncharacterized LOC105371089 Neighboring gene microRNA 4718 Neighboring gene ribosomal protein L35a pseudogene 34 Neighboring gene uncharacterized LOC105371092 Neighboring gene shisa family member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11151

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase CPPED1
Names
calcineurin-like phosphoesterase domain-containing protein 1
complete S-transactivated protein 1
NP_001092925.1
NP_060810.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099455.2NP_001092925.1  serine/threonine-protein phosphatase CPPED1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC010333, AC092324
    Consensus CDS
    CCDS42119.1
    UniProtKB/Swiss-Prot
    Q9BRF8
    Related
    ENSP00000411127.2, ENST00000433677.6
    Conserved Domains (1) summary
    cl13995
    Location:29153
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  2. NM_018340.3NP_060810.2  serine/threonine-protein phosphatase CPPED1 isoform a

    See identical proteins and their annotated locations for NP_060810.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC010333, AC092324
    Consensus CDS
    CCDS42120.1
    UniProtKB/Swiss-Prot
    Q9BRF8
    Related
    ENSP00000371193.4, ENST00000381774.9
    Conserved Domains (2) summary
    COG1409
    Location:67269
    CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]
    cd07395
    Location:29295
    MPP_CSTP1; Homo sapiens CSTP1 and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    12659799..12803887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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