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DDX19A DEAD-box helicase 19A [ Homo sapiens (human) ]

Gene ID: 55308, updated on 8-Aug-2021

Summary

Official Symbol
DDX19Aprovided by HGNC
Official Full Name
DEAD-box helicase 19Aprovided by HGNC
Primary source
HGNC:HGNC:25628
See related
Ensembl:ENSG00000168872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX19L; DDX19-DDX19L
Expression
Ubiquitous expression in thyroid (RPKM 14.8), placenta (RPKM 14.0) and 25 other tissues See more
Orthologs
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Genomic context

See DDX19A in Genome Data Viewer
Location:
16q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (70346871..70373383)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70380806..70407286)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7868 Neighboring gene DEAD-box helicase 19B Neighboring gene DDX19A divergent transcript Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene ribosomal protein S27 pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11126, DKFZp686C21137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX19A
Names
DDX19-like protein
DEAD (Asp-Glu-Ala-As) box polypeptide 19A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
DEAD box protein 19A
RNA helicase
NP_001307451.1
NP_001307454.1
NP_001307455.1
NP_001307456.1
NP_060802.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320522.2NP_001307451.1  ATP-dependent RNA helicase DDX19A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI863086, AK299539, BC005162, DB074731
    Consensus CDS
    CCDS82009.1
    UniProtKB/Swiss-Prot
    Q9NUU7
    UniProtKB/TrEMBL
    B4DS24, I3L0H8
    Related
    ENSP00000410243.2, ENST00000417604.6
    Conserved Domains (1) summary
    COG0513
    Location:100446
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
  2. NM_001320525.2NP_001307454.1  ATP-dependent RNA helicase DDX19A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI863086, BC005162, DB074731, DC375258
    UniProtKB/Swiss-Prot
    Q9NUU7
    Related
    ENSP00000460180.1, ENST00000575878.1
    Conserved Domains (2) summary
    cd18787
    Location:216352
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cl28899
    Location:9212
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  3. NM_001320526.2NP_001307455.1  ATP-dependent RNA helicase DDX19A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AI863086, BC005162, CR749227
    UniProtKB/Swiss-Prot
    Q9NUU7
    UniProtKB/TrEMBL
    Q68DY7
    Conserved Domains (3) summary
    COG0513
    Location:1327
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:156291
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:1145
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001320527.2NP_001307456.1  ATP-dependent RNA helicase DDX19A isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI863086, AK310604, BC005162, DB074731
    UniProtKB/Swiss-Prot
    Q9NUU7
    Conserved Domains (3) summary
    COG0513
    Location:34300
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:129264
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:34118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_018332.5NP_060802.1  ATP-dependent RNA helicase DDX19A isoform 1

    See identical proteins and their annotated locations for NP_060802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI863086, BC005162, DB074731
    Consensus CDS
    CCDS10889.1
    UniProtKB/Swiss-Prot
    Q9NUU7
    Related
    ENSP00000306117.7, ENST00000302243.12
    Conserved Domains (2) summary
    cd18787
    Location:306442
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cl28899
    Location:74302
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RNA

  1. NR_135296.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI863086, AK310804, BC005162, DB074731
    Related
    ENST00000569771.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    70346871..70373383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957830.1 RNA Sequence

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