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OLAH oleoyl-ACP hydrolase [ Homo sapiens (human) ]

Gene ID: 55301, updated on 13-Mar-2020

Summary

Official Symbol
OLAHprovided by HGNC
Official Full Name
oleoyl-ACP hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:25625
See related
Ensembl:ENSG00000152463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TE2; SAST; AURA1; THEDC1
Expression
Biased expression in testis (RPKM 8.6) and placenta (RPKM 2.3) See more
Orthologs

Genomic context

See OLAH in Genome Data Viewer
Location:
10p13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (15032224..15073853)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15085895..15115851)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 26 pseudogene Neighboring gene ACBD7-DCLRE1CP1 readthrough Neighboring gene olfactory receptor family 7 subfamily E member 115 pseudogene Neighboring gene DNA cross-link repair 1C pseudogene 1 Neighboring gene acyl-CoA binding domain containing 7 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 45

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11106, MGC51852

Gene Ontology Provided by GOA

Process Evidence Code Pubs
lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
medium-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
S-acyl fatty acid synthase thioesterase, medium chain
Names
augmented in rheumatoid arthritis 1
oleoyl-acyl-carrier-protein hydrolase
thioesterase 2
thioesterase II
thioesterase domain containing 1
thioesterase domain-containing protein 1
NP_001034791.1
NP_060794.1
XP_016871865.1
XP_024303828.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039702.3NP_001034791.1  S-acyl fatty acid synthase thioesterase, medium chain isoform 2

    See identical proteins and their annotated locations for NP_001034791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK001968, AL590365, BC050372, BG281536
    Consensus CDS
    CCDS31152.1
    UniProtKB/Swiss-Prot
    Q9NV23
    Related
    ENSP00000367473.3, ENST00000378228.7
    Conserved Domains (1) summary
    COG3208
    Location:22242
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
  2. NM_018324.3NP_060794.1  S-acyl fatty acid synthase thioesterase, medium chain isoform 1

    See identical proteins and their annotated locations for NP_060794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK001968, AL590365, BG281536, BI830605
    Consensus CDS
    CCDS7106.1
    UniProtKB/Swiss-Prot
    Q9NV23
    Related
    ENSP00000367462.3, ENST00000378217.3
    Conserved Domains (2) summary
    COG3208
    Location:22295
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
    pfam12697
    Location:106297
    Abhydrolase_6; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    15032224..15073853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448060.1XP_024303828.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X2

    Conserved Domains (1) summary
    COG3208
    Location:22242
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
  2. XM_017016376.2XP_016871865.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

    UniProtKB/Swiss-Prot
    Q9NV23
    Conserved Domains (2) summary
    COG3208
    Location:22295
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
    pfam12697
    Location:106297
    Abhydrolase_6; Alpha/beta hydrolase family
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