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OLAH oleoyl-ACP hydrolase [ Homo sapiens (human) ]

Gene ID: 55301, updated on 27-Nov-2024

Summary

Official Symbol
OLAHprovided by HGNC
Official Full Name
oleoyl-ACP hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:25625
See related
Ensembl:ENSG00000152463 AllianceGenome:HGNC:25625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TE2; SAST; AURA1; THEDC1
Summary
Enables fatty acyl-[ACP] hydrolase activity. Involved in medium-chain fatty acid biosynthetic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 8.6) and placenta (RPKM 2.3) See more
Orthologs
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Genomic context

See OLAH in Genome Data Viewer
Location:
10p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (15032195..15073853)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (15046189..15087828)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15085942..15115852)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 26 pseudogene Neighboring gene ACBD7-DCLRE1CP1 readthrough Neighboring gene olfactory receptor family 7 subfamily E member 115 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3088 Neighboring gene DNA cross-link repair 1C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3089 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15089045-15089853 Neighboring gene MPRA-validated peak869 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:15125454-15125977 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:15125978-15126500 Neighboring gene acyl-CoA binding domain containing 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2167 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 45

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11106, MGC51852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acyl-[ACP] hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in medium-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
S-acyl fatty acid synthase thioesterase, medium chain
Names
augmented in rheumatoid arthritis 1
oleoyl-acyl-carrier-protein hydrolase
thioesterase 2
thioesterase II
thioesterase domain containing 1
thioesterase domain-containing protein 1
type II thioesterase
NP_001034791.1
NP_060794.1
XP_016871865.1
XP_024303828.1
XP_047281379.1
XP_054222181.1
XP_054222182.1
XP_054222183.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039702.3NP_001034791.1  S-acyl fatty acid synthase thioesterase, medium chain isoform 2

    See identical proteins and their annotated locations for NP_001034791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK001968, AL590365, BC050372, BG281536
    Consensus CDS
    CCDS31152.1
    UniProtKB/Swiss-Prot
    Q5VUB6, Q9NUW1, Q9NV23
    Related
    ENSP00000367473.4, ENST00000378228.8
    Conserved Domains (1) summary
    COG3208
    Location:22242
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
  2. NM_018324.3NP_060794.1  S-acyl fatty acid synthase thioesterase, medium chain isoform 1

    See identical proteins and their annotated locations for NP_060794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK001968, AL590365, BG281536, BI830605
    Consensus CDS
    CCDS7106.1
    UniProtKB/Swiss-Prot
    Q9NV23
    Related
    ENSP00000367462.3, ENST00000378217.3
    Conserved Domains (2) summary
    COG3208
    Location:22295
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
    pfam12697
    Location:106297
    Abhydrolase_6; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    15032195..15073853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425423.1XP_047281379.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

  2. XM_024448060.2XP_024303828.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X2

    UniProtKB/Swiss-Prot
    Q5VUB6, Q9NUW1, Q9NV23
    Conserved Domains (1) summary
    COG3208
    Location:22242
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
  3. XM_017016376.3XP_016871865.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

    UniProtKB/Swiss-Prot
    Q9NV23
    Conserved Domains (2) summary
    COG3208
    Location:22295
    GrsT; Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism]
    pfam12697
    Location:106297
    Abhydrolase_6; Alpha/beta hydrolase family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    15046189..15087828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366207.1XP_054222182.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

  2. XM_054366208.1XP_054222183.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X2

    UniProtKB/Swiss-Prot
    Q5VUB6, Q9NUW1, Q9NV23
  3. XM_054366206.1XP_054222181.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1