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PI4K2B phosphatidylinositol 4-kinase type 2 beta [ Homo sapiens (human) ]

Gene ID: 55300, updated on 1-Jun-2020

Summary

Official Symbol
PI4K2Bprovided by HGNC
Official Full Name
phosphatidylinositol 4-kinase type 2 betaprovided by HGNC
Primary source
HGNC:HGNC:18215
See related
Ensembl:ENSG00000038210 MIM:612101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIK42B; PI4KIIB
Summary
This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in duodenum (RPKM 18.2), small intestine (RPKM 15.4) and 25 other tissues See more
Orthologs

Genomic context

See PI4K2B in Genome Data Viewer
Location:
4p15.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (25234033..25279204)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25235653..25280831)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Neighboring gene SEPSECS antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105374535 Neighboring gene zinc finger CCHC-type containing 4 Neighboring gene anaphase promoting complex subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 4-kinase type 2-beta
Names
PI4KII-BETA
phosphatidylinositol 4-kinase type-II beta
NP_060793.2
XP_005248231.1
XP_005248232.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052594.1 RefSeqGene

    Range
    5003..50174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018323.4NP_060793.2  phosphatidylinositol 4-kinase type 2-beta

    See identical proteins and their annotated locations for NP_060793.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC108218, AY091514, BC051749
    Consensus CDS
    CCDS3433.1
    UniProtKB/Swiss-Prot
    Q8TCG2
    Related
    ENSP00000264864.6, ENST00000264864.8
    Conserved Domains (1) summary
    pfam00454
    Location:130427
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RNA

  1. NR_144633.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104662, AC108218

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    25234033..25279204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248174.2XP_005248231.1  phosphatidylinositol 4-kinase type 2-beta isoform X1

    Conserved Domains (1) summary
    pfam00454
    Location:130422
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
  2. XM_005248175.4XP_005248232.1  phosphatidylinositol 4-kinase type 2-beta isoform X2

    See identical proteins and their annotated locations for XP_005248232.1

    UniProtKB/TrEMBL
    G5E9Z4
    Related
    ENSP00000423373.1, ENST00000512921.4
    Conserved Domains (1) summary
    pfam00454
    Location:34331
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
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