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PI4K2B phosphatidylinositol 4-kinase type 2 beta [ Homo sapiens (human) ]

Gene ID: 55300, updated on 10-Oct-2024

Summary

Official Symbol
PI4K2Bprovided by HGNC
Official Full Name
phosphatidylinositol 4-kinase type 2 betaprovided by HGNC
Primary source
HGNC:HGNC:18215
See related
Ensembl:ENSG00000038210 MIM:612101; AllianceGenome:HGNC:18215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIK42B; PI4KIIB
Summary
This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in duodenum (RPKM 18.2), small intestine (RPKM 15.4) and 25 other tissues See more
Orthologs
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Genomic context

See PI4K2B in Genome Data Viewer
Location:
4p15.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (25234033..25279204)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (25215954..25261023)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25235655..25280826)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:25133175-25133701 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:25133702-25134228 Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21370 Neighboring gene SEPSECS antisense RNA 1 (head to head) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21371 Neighboring gene uncharacterized LOC105374535 Neighboring gene H3K27ac hESC enhancers GRCh37_chr4:25235481-25235982 and GRCh37_chr4:25235983-25236482 Neighboring gene uncharacterized LOC124900916 Neighboring gene uncharacterized LOC124900685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:25314050-25314926 Neighboring gene uncharacterized LOC124900686 Neighboring gene zinc finger CCHC-type containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 1-phosphatidylinositol 4-kinase activity TAS
Traceable Author Statement
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphatidylinositol 4-kinase type 2-beta
Names
PI4KII-BETA
phosphatidylinositol 4-kinase type-II beta
NP_060793.2
XP_005248231.1
XP_005248232.1
XP_054206387.1
XP_054206388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052594.1 RefSeqGene

    Range
    5003..50174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018323.4NP_060793.2  phosphatidylinositol 4-kinase type 2-beta

    See identical proteins and their annotated locations for NP_060793.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC108218, AY091514, BC051749
    Consensus CDS
    CCDS3433.1
    UniProtKB/Swiss-Prot
    Q8TCG2, Q9NUW2
    UniProtKB/TrEMBL
    B3KY39
    Related
    ENSP00000264864.6, ENST00000264864.8
    Conserved Domains (1) summary
    pfam00454
    Location:130427
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RNA

  1. NR_144633.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104662, AC108218

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    25234033..25279204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248174.3XP_005248231.1  phosphatidylinositol 4-kinase type 2-beta isoform X1

    UniProtKB/TrEMBL
    B3KY39
    Conserved Domains (1) summary
    pfam00454
    Location:130422
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
  2. XM_005248175.5XP_005248232.1  phosphatidylinositol 4-kinase type 2-beta isoform X2

    See identical proteins and their annotated locations for XP_005248232.1

    UniProtKB/TrEMBL
    B4DJZ0, G5E9Z4
    Related
    ENSP00000423373.1, ENST00000512921.4
    Conserved Domains (1) summary
    pfam00454
    Location:34331
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RNA

  1. XR_007057941.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    25215954..25261023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350412.1XP_054206387.1  phosphatidylinositol 4-kinase type 2-beta isoform X1

  2. XM_054350413.1XP_054206388.1  phosphatidylinositol 4-kinase type 2-beta isoform X2

    UniProtKB/TrEMBL
    G5E9Z4

RNA

  1. XR_008487014.1 RNA Sequence