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UEVLD UEV and lactate/malate dehyrogenase domains [ Homo sapiens (human) ]

Gene ID: 55293, updated on 1-Aug-2020

Summary

Official Symbol
UEVLDprovided by HGNC
Official Full Name
UEV and lactate/malate dehyrogenase domainsprovided by HGNC
Primary source
HGNC:HGNC:30866
See related
Ensembl:ENSG00000151116 MIM:610985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATTP; UEV3
Expression
Ubiquitous expression in colon (RPKM 4.6), thyroid (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See UEVLD in Genome Data Viewer
Location:
11p15.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (18529606..18588734, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18551156..18610293, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A like 6A Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 13786 Neighboring gene uncharacterized LOC112268073 Neighboring gene mitochondrial carrier 1 pseudogene Neighboring gene SPTY2D1 opposite strand Neighboring gene SPT2 chromatin protein domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11068

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular protein modification process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 variant 3
Names
EV and lactate/malate dehydrogenase domain-containing protein
UEV-3
signaling molecule ATTP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040697.4NP_001035787.1  ubiquitin-conjugating enzyme E2 variant 3 isoform a

    See identical proteins and their annotated locations for NP_001035787.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC027544, AC112694
    Consensus CDS
    CCDS41624.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000379500.2, ENST00000396197.8
    Conserved Domains (3) summary
    cd05293
    Location:180468
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:161471
    PLN02602; lactate dehydrogenase
    pfam05743
    Location:21138
    UEV; UEV domain
  2. NM_001261382.3NP_001248311.1  ubiquitin-conjugating enzyme E2 variant 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC027544, AC112694
    Consensus CDS
    CCDS58124.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000368697.4, ENST00000379387.8
    Conserved Domains (3) summary
    cd05293
    Location:158446
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:139449
    PLN02602; lactate dehydrogenase
    pfam05743
    Location:21116
    UEV; UEV domain
  3. NM_001261383.3NP_001248312.1  ubiquitin-conjugating enzyme E2 variant 3 isoform d

    See identical proteins and their annotated locations for NP_001248312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region and an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (d) is shorter; it lacks an internal segment and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AC112694
    Consensus CDS
    CCDS58123.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000323353.6, ENST00000320750.10
    Conserved Domains (2) summary
    pfam05743
    Location:21116
    UEV; UEV domain
    cl21454
    Location:158339
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001261384.3NP_001248313.1  ubiquitin-conjugating enzyme E2 variant 3 isoform e

    See identical proteins and their annotated locations for NP_001248313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons in the 5' coding region, which results in a downstream start codon, compared to variant 1. The resulting isoform (e) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AC112694
    UniProtKB/TrEMBL
    B4DIA9
    Conserved Domains (2) summary
    cd05293
    Location:50338
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:31341
    PLN02602; lactate dehydrogenase
  5. NM_001261385.2NP_001248314.1  ubiquitin-conjugating enzyme E2 variant 3 isoform f

    See identical proteins and their annotated locations for NP_001248314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate 5' exon, which results in a downstream start codon, and also lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (f) is shorter and has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AC112694
    Consensus CDS
    CCDS58122.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000441092.1, ENST00000535484.5
    Conserved Domains (2) summary
    pfam05743
    Location:1100
    UEV; UEV domain
    cl21454
    Location:142323
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_001261386.3NP_001248315.1  ubiquitin-conjugating enzyme E2 variant 3 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences in the coding region, compared to variant 1. The resulting isoform (g) lacks two internal segments and has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AC112694
    Consensus CDS
    CCDS58125.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000437538.1, ENST00000541984.5
    Conserved Domains (2) summary
    cl00154
    Location:2167
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl21454
    Location:80196
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. NM_001297771.3NP_001284700.1  ubiquitin-conjugating enzyme E2 variant 3 isoform h

    See identical proteins and their annotated locations for NP_001284700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 3'-most exon in place of the last six exons compared to variant 1. The resulting isoform (h) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC027544, AC112694
    Consensus CDS
    CCDS73266.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000300038.7, ENST00000300038.7
    Conserved Domains (2) summary
    pfam05743
    Location:21138
    UEV; UEV domain
    cl21454
    Location:180204
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. NM_018314.6NP_060784.3  ubiquitin-conjugating enzyme E2 variant 3 isoform b

    See identical proteins and their annotated locations for NP_060784.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AC112694
    Consensus CDS
    CCDS7843.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000442974.1, ENST00000543987.5
    Conserved Domains (2) summary
    pfam05743
    Location:21138
    UEV; UEV domain
    cl21454
    Location:180361
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    18529606..18588734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040698.1: Suppressed sequence

    Description
    NM_001040698.1: This RefSeq was permanently suppressed because its 3' coding region is highly similar to an Alu repeat and the C-terminus of its protein has no support from any other proteins in the database.
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