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PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon [ Homo sapiens (human) ]

Gene ID: 5529, updated on 24-Nov-2020

Summary

Official Symbol
PPP2R5Eprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B'epsilonprovided by HGNC
Primary source
HGNC:HGNC:9313
See related
Ensembl:ENSG00000154001 MIM:601647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B56E; B56epsilon
Summary
The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in thyroid (RPKM 11.5), colon (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R5E in Genome Data Viewer
Location:
14q23.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (63371364..63543377, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (63839838..64010095, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370531 Neighboring gene ras homolog family member J Neighboring gene glycoprotein hormone subunit beta 5 Neighboring gene loricrin-like Neighboring gene ribosomal protein L31 pseudogene 5 Neighboring gene glycine C-acetyltransferase pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 2, regulatory subunit B', epsilon isoform (PPP2R5E) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat HIV-1 Tat associates with the promoters of both PPP2R1B and PPP2R5E to increase PPP2R1B and PPP2R5E RNA and protein levels as well as PP2A activity in Jurkat T cells PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with protein phosphatase 2, regulatory subunit B', epsilon isoform (PPP2R5E) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Names
PP2A, B subunit, B' epsilon
PP2A, B subunit, B56 epsilon
PP2A, B subunit, PR61 epsilon
PP2A, B subunit, R5 epsilon
protein phosphatase 2 regulatory subunit B', epsilon
serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, epsilon

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282179.3NP_001269108.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a

    See identical proteins and their annotated locations for NP_001269108.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AA782601, AB209811, AL118555, AL136038, AW134792, CB989123, CK820060, L76703
    Consensus CDS
    CCDS9758.1
    UniProtKB/Swiss-Prot
    Q16537
    Conserved Domains (2) summary
    pfam01603
    Location:55435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:267
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. NM_001282180.3NP_001269109.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform b

    See identical proteins and their annotated locations for NP_001269109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at an end of a 3' exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AA782601, AK299520, AL118555, AL132992, AL136038, AW134792, CB989123, CK820060, L76703
    Consensus CDS
    CCDS61468.1
    UniProtKB/Swiss-Prot
    Q16537
    Related
    ENSP00000452396.1, ENST00000555899.1
    Conserved Domains (2) summary
    pfam01603
    Location:55429
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:267
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  3. NM_001282181.3NP_001269110.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform c

    See identical proteins and their annotated locations for NP_001269110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (c).
    Source sequence(s)
    AA782601, AK301796, AL118555, AW134792, BC093766, CK820060, L76703
    Consensus CDS
    CCDS61467.1
    UniProtKB/Swiss-Prot
    Q16537
    Related
    ENSP00000404632.2, ENST00000422769.6
    Conserved Domains (1) summary
    pfam01603
    Location:2359
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  4. NM_001282182.3NP_001269111.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform c

    See identical proteins and their annotated locations for NP_001269111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (c).
    Source sequence(s)
    AA782601, AK301796, AK316430, AL118555, AW134792, BC093766, CK820060, L76703
    Consensus CDS
    CCDS61467.1
    UniProtKB/Swiss-Prot
    Q16537
    Conserved Domains (1) summary
    pfam01603
    Location:2359
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  5. NM_001354926.2NP_001341855.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform d

    Status: REVIEWED

    Source sequence(s)
    AL132992, AL136038, BC056156
    Related
    ENST00000556878.1
    Conserved Domains (1) summary
    cl27532
    Location:55120
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  6. NM_006246.5NP_006237.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a

    See identical proteins and their annotated locations for NP_006237.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AA782601, AL118555, AL136038, AW134792, BC093766, CB989123, CK820060, L76703
    Consensus CDS
    CCDS9758.1
    UniProtKB/Swiss-Prot
    Q16537
    Related
    ENSP00000337641.3, ENST00000337537.8
    Conserved Domains (2) summary
    pfam01603
    Location:55435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:267
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RNA

  1. NR_104104.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA782601, AL118555, AL136038, AW134792, BC013154, CB989123, CK820060, L76703

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    63371364..63543377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449647.1XP_024305415.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1

    Conserved Domains (2) summary
    pfam01603
    Location:55435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:267
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
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