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ACOXL acyl-CoA oxidase like [ Homo sapiens (human) ]

Gene ID: 55289, updated on 12-Aug-2022

Summary

Official Symbol
ACOXLprovided by HGNC
Official Full Name
acyl-CoA oxidase likeprovided by HGNC
Primary source
HGNC:HGNC:25621
See related
Ensembl:ENSG00000153093 AllianceGenome:HGNC:25621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be located in peroxisomal matrix. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ACOXL in Genome Data Viewer
Location:
2q13
Exon count:
33
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110732573..111118548)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (111155490..111541612)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111490150..111876125)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373554 Neighboring gene Sharpr-MPRA regulatory region 12654 Neighboring gene uncharacterized LOC124906064 Neighboring gene ribosomal protein L5 pseudogene 9 Neighboring gene uncharacterized LOC124907866 Neighboring gene Sharpr-MPRA regulatory region 7769 Neighboring gene ACOXL antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 8028 Neighboring gene BCL2 like 11 Neighboring gene uncharacterized LOC124907868

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
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EBI GWAS Catalog
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EBI GWAS Catalog
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
EBI GWAS Catalog
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
EBI GWAS Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 
enables acyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
acyl-coenzyme A oxidase-like protein
Names
acyl-CoA oxidase-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142807.4NP_001136279.1  acyl-coenzyme A oxidase-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023131, AC096591, AC096670, AC114776
    Consensus CDS
    CCDS46389.1
    UniProtKB/Swiss-Prot
    Q9NUZ1
    UniProtKB/TrEMBL
    B4DU63
    Related
    ENSP00000407761.1, ENST00000439055.6
    Conserved Domains (2) summary
    PLN02636
    Location:34545
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2545
    ACAD; Acyl-CoA dehydrogenase
  2. NM_001365487.2NP_001352416.1  acyl-coenzyme A oxidase-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC096591, AK300513, BC022268, HY017683
    Related
    ENSP00000343717.4, ENST00000340561.8
    Conserved Domains (1) summary
    cl09933
    Location:2261
    ACAD; Acyl-CoA dehydrogenase
  3. NM_001371254.1NP_001358183.1  acyl-coenzyme A oxidase-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC023131, AC096591, AC096670, AC114776
    UniProtKB/Swiss-Prot
    Q8TCE7
    Related
    ENSP00000374461.4, ENST00000389811.8
    Conserved Domains (1) summary
    cl09933
    Location:2544
    ACAD; Acyl-CoA dehydrogenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    110732573..111118548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511404.4XP_011509706.1  acyl-coenzyme A oxidase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011509706.1

    UniProtKB/TrEMBL
    A0A7I2V3X2
    Related
    ENSP00000503683.1, ENST00000676595.1
    Conserved Domains (2) summary
    PLN02636
    Location:34575
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2575
    ACAD; Acyl-CoA dehydrogenase
  2. XM_011511414.4XP_011509716.1  acyl-coenzyme A oxidase-like protein isoform X6

    Conserved Domains (1) summary
    cl09933
    Location:2522
    ACAD; Acyl-CoA dehydrogenase
  3. XM_047444905.1XP_047300861.1  acyl-coenzyme A oxidase-like protein isoform X9

  4. XM_011511411.4XP_011509713.1  acyl-coenzyme A oxidase-like protein isoform X4

    Conserved Domains (1) summary
    cl09933
    Location:2536
    ACAD; Acyl-CoA dehydrogenase
  5. XM_047444903.1XP_047300859.1  acyl-coenzyme A oxidase-like protein isoform X8

  6. XM_011511432.4XP_011509734.1  acyl-coenzyme A oxidase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011509734.1

    UniProtKB/TrEMBL
    A0A7I2V3X2
    Conserved Domains (2) summary
    PLN02636
    Location:34575
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2575
    ACAD; Acyl-CoA dehydrogenase
  7. XM_047444904.1XP_047300860.1  acyl-coenzyme A oxidase-like protein isoform X8

  8. XM_011511413.2XP_011509715.1  acyl-coenzyme A oxidase-like protein isoform X5

    Conserved Domains (2) summary
    PLN02636
    Location:34535
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2544
    ACAD; Acyl-CoA dehydrogenase
  9. XM_011511409.2XP_011509711.1  acyl-coenzyme A oxidase-like protein isoform X3

    Conserved Domains (2) summary
    PLN02636
    Location:34535
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2546
    ACAD; Acyl-CoA dehydrogenase
  10. XM_011511422.2XP_011509724.1  acyl-coenzyme A oxidase-like protein isoform X11

    See identical proteins and their annotated locations for XP_011509724.1

    Conserved Domains (1) summary
    cl09933
    Location:2489
    ACAD; Acyl-CoA dehydrogenase
  11. XM_011511415.3XP_011509717.1  acyl-coenzyme A oxidase-like protein isoform X7

    Conserved Domains (2) summary
    PLN02636
    Location:34552
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2544
    ACAD; Acyl-CoA dehydrogenase
  12. XM_011511421.3XP_011509723.1  acyl-coenzyme A oxidase-like protein isoform X11

    See identical proteins and their annotated locations for XP_011509723.1

    Conserved Domains (1) summary
    cl09933
    Location:2489
    ACAD; Acyl-CoA dehydrogenase
  13. XM_047444906.1XP_047300862.1  acyl-coenzyme A oxidase-like protein isoform X12

  14. XM_011511423.2XP_011509725.1  acyl-coenzyme A oxidase-like protein isoform X11

    See identical proteins and their annotated locations for XP_011509725.1

    Conserved Domains (1) summary
    cl09933
    Location:2489
    ACAD; Acyl-CoA dehydrogenase
  15. XM_011511419.3XP_011509721.1  acyl-coenzyme A oxidase-like protein isoform X10

    UniProtKB/Swiss-Prot
    Q9NUZ1
    Conserved Domains (2) summary
    PLN02636
    Location:34505
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2514
    ACAD; Acyl-CoA dehydrogenase
  16. XM_047444907.1XP_047300863.1  acyl-coenzyme A oxidase-like protein isoform X16

  17. XM_011511427.3XP_011509729.1  acyl-coenzyme A oxidase-like protein isoform X13

    Conserved Domains (1) summary
    cl09933
    Location:2486
    ACAD; Acyl-CoA dehydrogenase
  18. XM_011511429.3XP_011509731.1  acyl-coenzyme A oxidase-like protein isoform X15

    Conserved Domains (1) summary
    cl09933
    Location:2396
    ACAD; Acyl-CoA dehydrogenase
  19. XM_011511428.4XP_011509730.1  acyl-coenzyme A oxidase-like protein isoform X14

    Conserved Domains (1) summary
    cl09933
    Location:2396
    ACAD; Acyl-CoA dehydrogenase
  20. XM_017004431.2XP_016859920.1  acyl-coenzyme A oxidase-like protein isoform X17

  21. XM_047444908.1XP_047300864.1  acyl-coenzyme A oxidase-like protein isoform X20

  22. XM_017004432.3XP_016859921.1  acyl-coenzyme A oxidase-like protein isoform X18

  23. XM_011511405.4XP_011509707.1  acyl-coenzyme A oxidase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011509707.1

    UniProtKB/TrEMBL
    A0A7I2V3X2
    Conserved Domains (2) summary
    PLN02636
    Location:34575
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2575
    ACAD; Acyl-CoA dehydrogenase
  24. XM_011511406.4XP_011509708.1  acyl-coenzyme A oxidase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011509708.1

    UniProtKB/TrEMBL
    A0A7I2V3X2
    Conserved Domains (2) summary
    PLN02636
    Location:34575
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2575
    ACAD; Acyl-CoA dehydrogenase
  25. XM_011511407.4XP_011509709.1  acyl-coenzyme A oxidase-like protein isoform X2

    Conserved Domains (2) summary
    PLN02636
    Location:30571
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:33571
    ACAD; Acyl-CoA dehydrogenase
  26. XM_017004433.3XP_016859922.1  acyl-coenzyme A oxidase-like protein isoform X19

  27. XM_017004434.3XP_016859923.1  acyl-coenzyme A oxidase-like protein isoform X21

    Conserved Domains (2) summary
    PLN02636
    Location:1288
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:1288
    ACAD; Acyl-CoA dehydrogenase
  28. XM_011511434.4XP_011509736.1  acyl-coenzyme A oxidase-like protein isoform X21

    Conserved Domains (2) summary
    PLN02636
    Location:1288
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:1288
    ACAD; Acyl-CoA dehydrogenase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    111155490..111541612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105516.2: Suppressed sequence

    Description
    NM_001105516.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_001142808.1: Suppressed sequence

    Description
    NM_001142808.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_018308.1: Suppressed sequence

    Description
    NM_018308.1: This RefSeq was permanently suppressed because the CDS was partial.