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UBE2W ubiquitin conjugating enzyme E2 W [ Homo sapiens (human) ]

Gene ID: 55284, updated on 24-Nov-2020

Summary

Official Symbol
UBE2Wprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Wprovided by HGNC
Primary source
HGNC:HGNC:25616
See related
Ensembl:ENSG00000104343 MIM:614277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBC16; UBC-16
Summary
This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See UBE2W in Genome Data Viewer
Location:
8q21.11
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (73780096..73878862, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74692332..74791145, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene staufen double-stranded RNA binding protein 2 Neighboring gene uncharacterized LOC105375902 Neighboring gene VENT homeobox pseudogene 6 Neighboring gene RNA, 7SL, cytoplasmic 760, pseudogene Neighboring gene long intergenic non-protein coding RNA 1617 Neighboring gene glycogenin 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11011, FLJ41537

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to misfolded protein ISS
Inferred from Sequence or Structural Similarity
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein quality control for misfolded or incompletely synthesized proteins ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 W
Names
E2 ubiquitin-conjugating enzyme W
N-terminal E2 ubiquitin-conjugating enzyme
N-terminus-conjugating E2
ubiquitin carrier protein W
ubiquitin conjugating enzyme E2 W (putative)
ubiquitin conjugating enzyme E2W (putative)
ubiquitin-conjugating enzyme 16
ubiquitin-conjugating enzyme 2W
ubiquitin-protein ligase W
NP_001001481.3
NP_001257944.2
NP_060769.5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001481.4NP_001001481.3  ubiquitin-conjugating enzyme E2 W isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC022826, AK024050, BX538145
    Consensus CDS
    CCDS47875.2
    Related
    ENSP00000498255.1, ENST00000650817.1
    Conserved Domains (1) summary
    pfam00179
    Location:18159
    UQ_con; Ubiquitin-conjugating enzyme
  2. NM_001271015.3NP_001257944.2  ubiquitin-conjugating enzyme E2 W isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, lacks a portion of the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC022826, AK295792, BC010900
    Related
    ENSP00000428835.1, ENST00000523278.5
    Conserved Domains (1) summary
    pfam00179
    Location:7147
    UQ_con; Ubiquitin-conjugating enzyme
  3. NM_018299.6NP_060769.5  ubiquitin-conjugating enzyme E2 W isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC022826, AK295792, BC016326, BX538145
    Consensus CDS
    CCDS47874.2
    Related
    ENSP00000473561.1, ENST00000602593.6
    Conserved Domains (1) summary
    pfam00179
    Location:7148
    UQ_con; Ubiquitin-conjugating enzyme

RNA

  1. NR_073119.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two internal exons and contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022826, AK295792, BX538145, DA352184
  2. NR_073120.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two internal exons and contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022826, AK295792, BU155172, BX538145
  3. NR_073121.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022826, AK295792, BX538145, BX648427

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    73780096..73878862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001482.1: Suppressed sequence

    Description
    NM_001001482.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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