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PPP2R5D protein phosphatase 2 regulatory subunit B'delta [ Homo sapiens (human) ]

Gene ID: 5528, updated on 1-Jun-2020

Summary

Official Symbol
PPP2R5Dprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B'deltaprovided by HGNC
Primary source
HGNC:HGNC:9312
See related
Ensembl:ENSG00000112640 MIM:601646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B56D; MRD35; B56delta
Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 23.6), brain (RPKM 18.9) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R5D in Genome Data Viewer
Location:
6p21.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (42984570..43012342)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42952218..42980083)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CNPY3-GNMT readthrough Neighboring gene RPL24 pseudogene 4 Neighboring gene glycine N-methyltransferase Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene male-enhanced antigen 1 Neighboring gene kelch domain containing 3 Neighboring gene ribosomal RNA processing 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2134, MGC8949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Names
PP2A, B subunit, B' delta isoform
PP2A, B subunit, B56 delta isoform
PP2A, B subunit, PR61 delta isoform
PP2A, B subunit, R5 delta isoform
Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform
protein phosphatase 2, regulatory subunit B (B56), delta isoform

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050636.1 RefSeqGene

    Range
    5072..32844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270476.2NP_001257405.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 4

    See identical proteins and their annotated locations for NP_001257405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 5' end of an exon compared to variant 1, resulting in a transcript that is translated from a downstream AUG. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK122701, AL136304, BC001095, DA388594
    UniProtKB/Swiss-Prot
    Q14738
    Conserved Domains (1) summary
    pfam01603
    Location:1362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. NM_006245.4NP_006236.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 1

    See identical proteins and their annotated locations for NP_006236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1).
    Source sequence(s)
    BC010692, DA388594
    Consensus CDS
    CCDS4878.1
    UniProtKB/Swiss-Prot
    Q14738
    UniProtKB/TrEMBL
    A0A024RD11
    Related
    ENSP00000417963.1, ENST00000485511.6
    Conserved Domains (2) summary
    pfam01603
    Location:108513
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:56122
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  3. NM_180976.3NP_851307.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 2

    See identical proteins and their annotated locations for NP_851307.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2), that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    BC001175, DA388594
    Consensus CDS
    CCDS55002.1
    UniProtKB/Swiss-Prot
    Q14738
    Related
    ENSP00000377669.3, ENST00000394110.7
    Conserved Domains (1) summary
    pfam01603
    Location:82481
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  4. NM_180977.3NP_851308.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 3

    See identical proteins and their annotated locations for NP_851308.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AB000635, BC001095, DA388594
    Consensus CDS
    CCDS43464.1
    UniProtKB/Swiss-Prot
    Q14738
    Related
    ENSP00000420674.1, ENST00000461010.5
    Conserved Domains (1) summary
    pfam01603
    Location:6407
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    42984570..43012342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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