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ZNF654 zinc finger protein 654 [ Homo sapiens (human) ]

Gene ID: 55279, updated on 5-Aug-2022

Summary

Official Symbol
ZNF654provided by HGNC
Official Full Name
zinc finger protein 654provided by HGNC
Primary source
HGNC:HGNC:25612
See related
Ensembl:ENSG00000175105 AllianceGenome:HGNC:25612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.4), thyroid (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF654 in Genome Data Viewer
Location:
3p11.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (88059255..88144660)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (88135096..88220495)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (88108405..88193810)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr3.2985 Neighboring gene 5-hydroxytryptamine receptor 1F Neighboring gene RNA, U6atac small nuclear 6, pseudogene Neighboring gene CGG triplet repeat binding protein 1 Neighboring gene chromobox 5 pseudogene 1 Neighboring gene chromosome 3 open reading frame 38 Neighboring gene uncharacterized LOC105377202 Neighboring gene ATP binding cassette subfamily F member 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10997, FLJ21142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 654
Names
melanoma-associated antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350134.2NP_001337063.1  zinc finger protein 654 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA767937, AC119733, AC128650
    Consensus CDS
    CCDS87110.1
    UniProtKB/Swiss-Prot
    Q9NV14
    Related
    ENSP00000490842.1, ENST00000636215.2
    Conserved Domains (2) summary
    sd00017
    Location:789809
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:547566
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001350135.2NP_001337064.1  zinc finger protein 654 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA767937, AC119733, AC128650
    Conserved Domains (2) summary
    sd00017
    Location:676696
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam08580
    Location:757957
    KAR9; Yeast cortical protein KAR9
  3. NM_001350136.2NP_001337065.1  zinc finger protein 654 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA767937, AC119733, AC128650
    Conserved Domains (2) summary
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam08580
    Location:658858
    KAR9; Yeast cortical protein KAR9
  4. NM_001350137.2NP_001337066.1  zinc finger protein 654 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA767937, AC119733, AC128650
    Conserved Domains (2) summary
    sd00017
    Location:515535
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam08580
    Location:596796
    KAR9; Yeast cortical protein KAR9
  5. NM_001366093.1NP_001353022.1  zinc finger protein 654 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119733, AC128650
    Conserved Domains (2) summary
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam08580
    Location:658858
    KAR9; Yeast cortical protein KAR9
  6. NM_001366095.1NP_001353024.1  zinc finger protein 654 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119733, AC128650
    Conserved Domains (2) summary
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam08580
    Location:658858
    KAR9; Yeast cortical protein KAR9
  7. NM_001366096.1NP_001353025.1  zinc finger protein 654 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119733, AC128650
    Conserved Domains (2) summary
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam08580
    Location:658858
    KAR9; Yeast cortical protein KAR9
  8. NM_001366097.1NP_001353026.1  zinc finger protein 654 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC119733, AC128650
    Conserved Domains (2) summary
    sd00017
    Location:515535
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam08580
    Location:596796
    KAR9; Yeast cortical protein KAR9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    88059255..88144660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006789.3XP_016862278.1  zinc finger protein 654 isoform X1

  2. XM_017006791.3XP_016862280.1  zinc finger protein 654 isoform X2

  3. XM_047448514.1XP_047304470.1  zinc finger protein 654 isoform X3

  4. XM_024453623.2XP_024309391.1  zinc finger protein 654 isoform X4

    Conserved Domains (4) summary
    sd00017
    Location:515535
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:273292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam08580
    Location:596796
    KAR9; Yeast cortical protein KAR9
    pfam15909
    Location:543595
    zf-C2H2_8; C2H2-type zinc ribbon

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    88135096..88220495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018293.2: Suppressed sequence

    Description
    NM_018293.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
  2. NM_032198.1: Suppressed sequence

    Description
    NM_032198.1: This RefSeq was temporarily suppressed because the CDS was partial.