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QRSL1 glutaminyl-tRNA amidotransferase subunit QRSL1 [ Homo sapiens (human) ]

Gene ID: 55278, updated on 6-Sep-2022

Summary

Official Symbol
QRSL1provided by HGNC
Official Full Name
glutaminyl-tRNA amidotransferase subunit QRSL1provided by HGNC
Primary source
HGNC:HGNC:21020
See related
Ensembl:ENSG00000130348 MIM:617209; AllianceGenome:HGNC:21020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GatA; COXPD40
Summary
Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 40. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 7.2), thyroid (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See QRSL1 in Genome Data Viewer
Location:
6q21
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (106629578..106668417)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (107806065..107844870)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (107077453..107116292)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene reticulon 4 interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 441 Neighboring gene RNA, U6 small nuclear 527, pseudogene Neighboring gene ribosomal protein L21 pseudogene 65 Neighboring gene long intergenic non-protein coding RNA 2526 Neighboring gene uncharacterized LOC105377927

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10989, FLJ12189, FLJ13447, DKFZp564C1278

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of glutamyl-tRNA(Gln) amidotransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of glutamyl-tRNA(Gln) amidotransferase complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Names
QRSL1, glutaminyl-tRNA amidotransferase subunit A
glu-AdT subunit A
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
glutaminyl-tRNA synthase-like protein 1
glutamyl-tRNA(Gln) amidotransferase subunit A homolog
glutamyl-tRNA(Gln) amidotransferase, subunit A
NP_060762.3
XP_011534226.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018292.5NP_060762.3  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

    See identical proteins and their annotated locations for NP_060762.3

    Status: VALIDATED

    Source sequence(s)
    AL390074, BC014389, DA819470
    Consensus CDS
    CCDS5057.1
    UniProtKB/Swiss-Prot
    Q9H0R6, Q9NV19
    Related
    ENSP00000358042.4, ENST00000369046.8
    Conserved Domains (1) summary
    PRK00012
    Location:13495
    gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    106629578..106668417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535924.3XP_011534226.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011534226.1

    Conserved Domains (1) summary
    PRK00012
    Location:1404
    gatA; Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    107806065..107844870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)