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FGGY FGGY carbohydrate kinase domain containing [ Homo sapiens (human) ]

Gene ID: 55277, updated on 21-Jun-2020

Summary

Official Symbol
FGGYprovided by HGNC
Official Full Name
FGGY carbohydrate kinase domain containingprovided by HGNC
Primary source
HGNC:HGNC:25610
See related
Ensembl:ENSG00000172456 MIM:611370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in liver (RPKM 2.1), kidney (RPKM 1.3) and 25 other tissues See more
Orthologs

Genomic context

See FGGY in Genome Data Viewer
Location:
1p32.1
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (59296405..59762730)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (59762625..60228402)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1358 Neighboring gene VISTA enhancer hs1485 Neighboring gene uncharacterized LOC729467 Neighboring gene uncharacterized LOC105378756 Neighboring gene Sharpr-MPRA regulatory region 6224 Neighboring gene uncharacterized LOC101926944 Neighboring gene microRNA 4711 Neighboring gene uncharacterized LOC105378758 Neighboring gene hook microtubule tethering protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
NHGRI GWA Catalog
Genomewide association study of movement-related adverse antipsychotic effects.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10986

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-ribulokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pentose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
pentose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
FGGY carbohydrate kinase domain-containing protein
Names
D-ribulokinase
NP_001106882.1
NP_001231643.1
NP_001265153.1
NP_001337719.1
NP_001337720.1
NP_001337721.1
NP_001337722.1
NP_001337723.1
NP_001337724.1
NP_001337725.1
NP_001337726.1
NP_001337727.1
NP_001337728.1
NP_060761.3
XP_011540032.1
XP_011540033.1
XP_011540038.1
XP_016857132.1
XP_016857134.1
XP_016857135.1
XP_016857138.1
XP_016857141.1
XP_016857144.1
XP_016857145.1
XP_016857146.1
XP_016857148.1
XP_016857149.1
XP_016857150.1
XP_016857151.1
XP_016857152.1
XP_016857153.1
XP_016857157.1
XP_016857158.1
XP_016857159.1
XP_016857160.1
XP_016857162.1
XP_016857166.1
XP_016857167.1
XP_016857168.1
XP_024303944.1
XP_024303953.1
XP_024303964.1
XP_024303975.1
XP_024303988.1
XP_024303995.1
XP_024303997.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030039.1 RefSeqGene

    Range
    5142..470775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001113411.2NP_001106882.1  FGGY carbohydrate kinase domain-containing protein isoform a

    See identical proteins and their annotated locations for NP_001106882.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 6 encode the same protein (isoform a).
    Source sequence(s)
    AA830864, BC014947, BX647626
    Consensus CDS
    CCDS44155.1
    UniProtKB/Swiss-Prot
    Q96C11
    Related
    ENSP00000360262.4, ENST00000371218.8
    Conserved Domains (1) summary
    cd07782
    Location:10568
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  2. NM_001244714.2NP_001231643.1  FGGY carbohydrate kinase domain-containing protein isoform c

    See identical proteins and their annotated locations for NP_001231643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC093424, AK054842, BU630162, DA072156
    Consensus CDS
    CCDS58003.1
    UniProtKB/Swiss-Prot
    Q96C11
    Related
    ENSP00000360256.1, ENST00000371212.5
    Conserved Domains (2) summary
    cd07782
    Location:10456
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
    TIGR01315
    Location:11456
    5C_CHO_kinase; FGGY-family pentulose kinase
  3. NM_001278224.2NP_001265153.1  FGGY carbohydrate kinase domain-containing protein isoform d

    See identical proteins and their annotated locations for NP_001265153.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL390234, BC014947
    Consensus CDS
    CCDS60155.1
    UniProtKB/Swiss-Prot
    Q96C11
    Related
    ENSP00000360254.1, ENST00000371210.1
    Conserved Domains (1) summary
    cl17037
    Location:1245
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. NM_001350790.2NP_001337719.1  FGGY carbohydrate kinase domain-containing protein isoform a

    Status: REVIEWED

    Source sequence(s)
    AA830864, AC093424, AK054842, BC014947, BX647626, DA072156
    Consensus CDS
    CCDS44155.1
    Conserved Domains (1) summary
    cd07782
    Location:10568
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  5. NM_001350791.2NP_001337720.1  FGGY carbohydrate kinase domain-containing protein isoform b

    Status: REVIEWED

    Source sequence(s)
    AC093424, AK054842, BC014947, DA072156
    Consensus CDS
    CCDS611.2
    Conserved Domains (1) summary
    cd07782
    Location:10544
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  6. NM_001350792.2NP_001337721.1  FGGY carbohydrate kinase domain-containing protein isoform e

    Status: REVIEWED

    Source sequence(s)
    AC093424, AK054842, BI260394, BU630162, DA072156
    Conserved Domains (1) summary
    cd07782
    Location:12488
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  7. NM_001350793.2NP_001337722.1  FGGY carbohydrate kinase domain-containing protein isoform e

    Status: REVIEWED

    Source sequence(s)
    AC093424, AK054842, BI260394, BU630162, DA270957
    Conserved Domains (1) summary
    cd07782
    Location:12488
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  8. NM_001350794.2NP_001337723.1  FGGY carbohydrate kinase domain-containing protein isoform f

    Status: REVIEWED

    Source sequence(s)
    AC093424, AK054842, BM688624, BU630162, CA425949, DA072156, DN990967
    Conserved Domains (1) summary
    cd07782
    Location:10473
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  9. NM_001350795.2NP_001337724.1  FGGY carbohydrate kinase domain-containing protein isoform g

    Status: REVIEWED

    Source sequence(s)
    AA830864, BC014947, BX647626
    Conserved Domains (1) summary
    cd07782
    Location:10480
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  10. NM_001350796.2NP_001337725.1  FGGY carbohydrate kinase domain-containing protein isoform h

    Status: REVIEWED

    Source sequence(s)
    AK054842, BU630162, DA270957
    Conserved Domains (1) summary
    cd07782
    Location:1432
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  11. NM_001350797.2NP_001337726.1  FGGY carbohydrate kinase domain-containing protein isoform i

    Status: REVIEWED

    Source sequence(s)
    AC093424, AK054842, BI260394, BU630162, DA270957
    Conserved Domains (1) summary
    cd07782
    Location:1410
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  12. NM_001350798.2NP_001337727.1  FGGY carbohydrate kinase domain-containing protein isoform j

    Status: REVIEWED

    Source sequence(s)
    AK054842, BU630162, BX647626, DA270957
    Conserved Domains (1) summary
    cd07782
    Location:1385
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  13. NM_001350799.2NP_001337728.1  FGGY carbohydrate kinase domain-containing protein isoform k

    Status: REVIEWED

    Source sequence(s)
    AC093424, AK054842, BM688624, BU630162, DA072156, DA270957
    Conserved Domains (1) summary
    cd07782
    Location:1361
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  14. NM_018291.5NP_060761.3  FGGY carbohydrate kinase domain-containing protein isoform b

    See identical proteins and their annotated locations for NP_060761.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2 and 7 encode the same protein (isoform b).
    Source sequence(s)
    AL035416, BC014947
    Consensus CDS
    CCDS611.2
    UniProtKB/Swiss-Prot
    Q96C11
    Related
    ENSP00000305922.7, ENST00000303721.11
    Conserved Domains (1) summary
    cd07782
    Location:10544
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

RNA

  1. NR_103473.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains multiple differences at the 5' and 3' ends, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK090568, BC014947
    Related
    ENST00000430447.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    59296405..59762730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541731.1XP_011540033.1  FGGY carbohydrate kinase domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011540033.1

    UniProtKB/Swiss-Prot
    Q96C11
    Conserved Domains (1) summary
    cd07782
    Location:10568
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  2. XM_017001659.2XP_016857148.1  FGGY carbohydrate kinase domain-containing protein isoform X7

  3. XM_011541730.1XP_011540032.1  FGGY carbohydrate kinase domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011540032.1

    UniProtKB/Swiss-Prot
    Q96C11
    Conserved Domains (1) summary
    cd07782
    Location:10568
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  4. XM_017001645.1XP_016857134.1  FGGY carbohydrate kinase domain-containing protein isoform X2

    UniProtKB/Swiss-Prot
    Q96C11
    Conserved Domains (1) summary
    cd07782
    Location:10544
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  5. XM_024448207.1XP_024303975.1  FGGY carbohydrate kinase domain-containing protein isoform X5

    Conserved Domains (1) summary
    cd07782
    Location:10473
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  6. XM_017001655.1XP_016857144.1  FGGY carbohydrate kinase domain-containing protein isoform X6

    Conserved Domains (1) summary
    cd07782
    Location:10480
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  7. XM_017001671.1XP_016857160.1  FGGY carbohydrate kinase domain-containing protein isoform X9

  8. XM_017001663.2XP_016857152.1  FGGY carbohydrate kinase domain-containing protein isoform X7

  9. XM_017001656.1XP_016857145.1  FGGY carbohydrate kinase domain-containing protein isoform X7

  10. XM_017001669.2XP_016857158.1  FGGY carbohydrate kinase domain-containing protein isoform X9

  11. XM_017001664.2XP_016857153.1  FGGY carbohydrate kinase domain-containing protein isoform X7

  12. XM_017001660.2XP_016857149.1  FGGY carbohydrate kinase domain-containing protein isoform X7

  13. XM_024448220.1XP_024303988.1  FGGY carbohydrate kinase domain-containing protein isoform X10

    Conserved Domains (1) summary
    cd07782
    Location:1432
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  14. XM_024448176.1XP_024303944.1  FGGY carbohydrate kinase domain-containing protein isoform X1

    Conserved Domains (1) summary
    cd07782
    Location:10568
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  15. XM_017001649.1XP_016857138.1  FGGY carbohydrate kinase domain-containing protein isoform X4

    Conserved Domains (1) summary
    cd07782
    Location:10497
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  16. XM_017001652.1XP_016857141.1  FGGY carbohydrate kinase domain-containing protein isoform X5

    Conserved Domains (1) summary
    cd07782
    Location:10473
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  17. XM_017001679.1XP_016857168.1  FGGY carbohydrate kinase domain-containing protein isoform X12

    Conserved Domains (1) summary
    cd07782
    Location:10358
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  18. XM_011541736.3XP_011540038.1  FGGY carbohydrate kinase domain-containing protein isoform X6

    See identical proteins and their annotated locations for XP_011540038.1

    Conserved Domains (1) summary
    cd07782
    Location:10480
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  19. XM_017001661.2XP_016857150.1  FGGY carbohydrate kinase domain-containing protein isoform X7

  20. XM_017001643.2XP_016857132.1  FGGY carbohydrate kinase domain-containing protein isoform X1

    UniProtKB/Swiss-Prot
    Q96C11
    Conserved Domains (1) summary
    cd07782
    Location:10568
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  21. XM_024448185.1XP_024303953.1  FGGY carbohydrate kinase domain-containing protein isoform X3

    Conserved Domains (1) summary
    cd07782
    Location:12512
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  22. XM_017001673.2XP_016857162.1  FGGY carbohydrate kinase domain-containing protein isoform X10

    UniProtKB/Swiss-Prot
    Q96C11
    Conserved Domains (1) summary
    cd07782
    Location:1432
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  23. XM_017001646.1XP_016857135.1  FGGY carbohydrate kinase domain-containing protein isoform X2

    UniProtKB/Swiss-Prot
    Q96C11
    Conserved Domains (1) summary
    cd07782
    Location:10544
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  24. XM_017001668.1XP_016857157.1  FGGY carbohydrate kinase domain-containing protein isoform X9

  25. XM_017001670.2XP_016857159.1  FGGY carbohydrate kinase domain-containing protein isoform X9

  26. XM_024448196.1XP_024303964.1  FGGY carbohydrate kinase domain-containing protein isoform X3

    Conserved Domains (1) summary
    cd07782
    Location:12512
    FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
  27. XM_017001657.2XP_016857146.1  FGGY carbohydrate kinase domain-containing protein isoform X7

  28. XM_017001662.2XP_016857151.1  FGGY carbohydrate kinase domain-containing protein isoform X7

  29. XM_017001678.1XP_016857167.1  FGGY carbohydrate kinase domain-containing protein isoform X11

    Conserved Domains (1) summary
    cl17037
    Location:2360
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  30. XM_024448229.1XP_024303997.1  FGGY carbohydrate kinase domain-containing protein isoform X13

    Conserved Domains (1) summary
    cl17037
    Location:2336
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  31. XM_017001677.1XP_016857166.1  FGGY carbohydrate kinase domain-containing protein isoform X11

    Conserved Domains (1) summary
    cl17037
    Location:2360
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  32. XM_024448227.1XP_024303995.1  FGGY carbohydrate kinase domain-containing protein isoform X13

    Conserved Domains (1) summary
    cl17037
    Location:2336
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. XR_001737285.1 RNA Sequence

  2. XR_001737284.1 RNA Sequence

  3. XR_001737287.1 RNA Sequence

  4. XR_001737286.1 RNA Sequence

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