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MAP11 microtubule associated protein 11 [ Homo sapiens (human) ]

Gene ID: 55262, updated on 9-Feb-2020

Summary

Official Symbol
MAP11provided by HGNC
Official Full Name
microtubule associated protein 11provided by HGNC
Primary source
HGNC:HGNC:25604
See related
Ensembl:ENSG00000146826 MIM:618350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCPH25; C7orf43; TRAPPC14
Expression
Ubiquitous expression in testis (RPKM 16.4), spleen (RPKM 11.5) and 25 other tissues See more
Orthologs

Genomic context

See MAP11 in Genome Data Viewer
Location:
7q22.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100154423..100158723, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99752043..99756338, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene metallo-beta-lactamase domain containing 1 Neighboring gene ribosomal protein L7 pseudogene 60 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene microRNA 4658 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene glypican 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10925, DKFZp761G0712

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
microtubule-associated protein 11
Names
uncharacterized protein C7orf43

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303470.2NP_001290399.1  microtubule-associated protein 11 isoform 2

    See identical proteins and their annotated locations for NP_001290399.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC073842, AK054872, BC094727, HY066862
    Consensus CDS
    CCDS78261.1
    UniProtKB/TrEMBL
    B3KNS5
    Related
    ENSP00000389672.2, ENST00000456769.5
    Conserved Domains (1) summary
    pfam15806
    Location:1310
    DUF4707; Domain of unknown function (DUF4707)
  2. NM_018275.5NP_060745.3  microtubule-associated protein 11 isoform 1

    See identical proteins and their annotated locations for NP_060745.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC073842, BC015722, BC094727, HY066862
    Consensus CDS
    CCDS5687.1
    UniProtKB/Swiss-Prot
    Q8WVR3
    Related
    ENSP00000324741.3, ENST00000316937.8
    Conserved Domains (1) summary
    pfam15806
    Location:139579
    DUF4707; Domain of unknown function (DUF4707)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100154423..100158723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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