Format

Send to:

Choose Destination

TMEM143 transmembrane protein 143 [ Homo sapiens (human) ]

Gene ID: 55260, updated on 1-Jun-2020

Summary

Official Symbol
TMEM143provided by HGNC
Official Full Name
transmembrane protein 143provided by HGNC
Primary source
HGNC:HGNC:25603
See related
Ensembl:ENSG00000161558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in heart (RPKM 9.0), fat (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See TMEM143 in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48332356..48363940, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48835613..48867489, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 114 Neighboring gene Sharpr-MPRA regulatory region 73 Neighboring gene epithelial membrane protein 3 Neighboring gene synaptogyrin 4 Neighboring gene KDEL endoplasmic reticulum protein retention receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10922

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303538.2NP_001290467.1  transmembrane protein 143 isoform b

    See identical proteins and their annotated locations for NP_001290467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC008392, AK297610, AW136519, DC357566
    Consensus CDS
    CCDS77326.1
    UniProtKB/TrEMBL
    B4DMT0
    Related
    ENSP00000397038.2, ENST00000435956.7
    Conserved Domains (1) summary
    pfam12576
    Location:194316
    DUF3754; Protein of unknown function (DUF3754)
  2. NM_001303539.2NP_001290468.1  transmembrane protein 143 isoform c

    See identical proteins and their annotated locations for NP_001290468.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC008392, AK298317, AW136519, DC357566
    UniProtKB/TrEMBL
    B4DPF8
    Conserved Domains (1) summary
    pfam12576
    Location:164286
    DUF3754; Protein of unknown function (DUF3754)
  3. NM_001303540.2NP_001290469.1  transmembrane protein 143 isoform d

    See identical proteins and their annotated locations for NP_001290469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC008392, AW136519, AY358161, DC357566
    Consensus CDS
    CCDS77325.1
    UniProtKB/Swiss-Prot
    Q96AN5
    Related
    ENSP00000366649.1, ENST00000377431.6
    Conserved Domains (1) summary
    pfam12576
    Location:129251
    DUF3754; Protein of unknown function (DUF3754)
  4. NM_018273.4NP_060743.2  transmembrane protein 143 isoform a

    See identical proteins and their annotated locations for NP_060743.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC008392, AW136519, BC016919, DC357566
    Consensus CDS
    CCDS12716.1
    UniProtKB/Swiss-Prot
    Q96AN5
    Related
    ENSP00000293261.2, ENST00000293261.8
    Conserved Domains (1) summary
    pfam12576
    Location:229351
    DUF3754; Protein of unknown function (DUF3754)

RNA

  1. NR_130317.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008392, AC020955, AK297591, AW136519, DC357566

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48332356..48363940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center