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THNSL2 threonine synthase like 2 [ Homo sapiens (human) ]

Gene ID: 55258, updated on 20-Jun-2020

Summary

Official Symbol
THNSL2provided by HGNC
Official Full Name
threonine synthase like 2provided by HGNC
Primary source
HGNC:HGNC:25602
See related
Ensembl:ENSG00000144115 MIM:611261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THS2; TSH2; SOFAT
Summary
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in kidney (RPKM 9.9), thyroid (RPKM 9.5) and 24 other tissues See more
Orthologs

Genomic context

See THNSL2 in Genome Data Viewer
Location:
2p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (88170295..88186637)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (88469814..88486156)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 1 Neighboring gene microRNA 4780 Neighboring gene uncharacterized LOC101928347 Neighboring gene fatty acid binding protein 1 Neighboring gene RNY4 pseudogene 15 Neighboring gene mitochondrial ribosomal protein L45 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of threonine synthase-like 2 (THNSL2) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10916, FLJ35504

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyridoxal phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
serine binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT threonine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
2-oxobutyrate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
2-oxobutyrate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
biological_process ND
No biological Data available
more info
 
dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
serine family amino acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine family amino acid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
threonine synthase-like 2
Names
secreted osteoclastogenic factor of activated T cells
NP_001231605.1
NP_001231607.1
NP_060741.3
XP_005264457.1
XP_005264458.1
XP_005264459.1
XP_005264460.1
XP_005264462.1
XP_006712104.1
XP_006712105.1
XP_006712106.1
XP_006712107.1
XP_011531255.1
XP_011531256.1
XP_011531257.1
XP_024308743.1
XP_024308744.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030037.1 RefSeqGene

    Range
    5001..21343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244676.1NP_001231605.1  threonine synthase-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001231605.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a longer 5' UTR and uses an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC092836, AI313402, BC064423, BI765911
    Consensus CDS
    CCDS58718.1
    UniProtKB/Swiss-Prot
    Q86YJ6
    Related
    ENSP00000339563.4, ENST00000343544.8
    Conserved Domains (1) summary
    cd01560
    Location:2359
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
  2. NM_001244678.1NP_001231607.1  threonine synthase-like 2 isoform 3

    See identical proteins and their annotated locations for NP_001231607.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC092836, AI313402, AK315831, BI765911
    Consensus CDS
    CCDS74539.1
    UniProtKB/TrEMBL
    A8K0C1
    Related
    ENSP00000366464.4, ENST00000377254.7
    Conserved Domains (1) summary
    cl00342
    Location:1201
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  3. NM_001384382.1NP_001371311.1  threonine synthase-like 2

    Status: REVIEWED

    Source sequence(s)
    AC092836
  4. NM_001384383.1NP_001371312.1  threonine synthase-like 2

    Status: REVIEWED

    Source sequence(s)
    AC092836
  5. NM_018271.5NP_060741.3  threonine synthase-like 2 isoform 1

    See identical proteins and their annotated locations for NP_060741.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092836
    Consensus CDS
    CCDS2002.2
    UniProtKB/Swiss-Prot
    Q86YJ6
    Related
    ENSP00000327323.5, ENST00000324166.6
    Conserved Domains (1) summary
    cd01560
    Location:2464
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    88170295..88186637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264400.4XP_005264457.1  threonine synthase-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q86YJ6
    Related
    ENSP00000501453.1, ENST00000674334.1
    Conserved Domains (1) summary
    cd01560
    Location:2464
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
  2. XM_024452975.1XP_024308743.1  threonine synthase-like 2 isoform X1

    Conserved Domains (1) summary
    cd01560
    Location:2464
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
  3. XM_011532955.2XP_011531257.1  threonine synthase-like 2 isoform X10

    Conserved Domains (1) summary
    cl00342
    Location:1306
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  4. XM_024452976.1XP_024308744.1  threonine synthase-like 2 isoform X12

  5. XM_005264401.5XP_005264458.1  threonine synthase-like 2 isoform X1

    See identical proteins and their annotated locations for XP_005264458.1

    UniProtKB/Swiss-Prot
    Q86YJ6
    Conserved Domains (1) summary
    cd01560
    Location:2464
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
  6. XM_006712041.3XP_006712104.1  threonine synthase-like 2 isoform X3

    Related
    ENST00000674169.1
    Conserved Domains (2) summary
    cd01560
    Location:2408
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK09225
    Location:1397
    PRK09225; threonine synthase; Validated
  7. XM_005264403.4XP_005264460.1  threonine synthase-like 2 isoform X8

    UniProtKB/Swiss-Prot
    Q86YJ6
    Related
    ENSP00000501447.1, ENST00000496844.6
    Conserved Domains (1) summary
    cd01560
    Location:2359
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
  8. XM_005264405.4XP_005264462.1  threonine synthase-like 2 isoform X9

    Conserved Domains (1) summary
    cd01560
    Location:2359
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
  9. XM_006712044.3XP_006712107.1  threonine synthase-like 2 isoform X11

    Related
    ENSP00000407553.1, ENST00000449349.5
    Conserved Domains (1) summary
    cl00342
    Location:2268
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  10. XM_011532954.2XP_011531256.1  threonine synthase-like 2 isoform X6

    Conserved Domains (2) summary
    cd01560
    Location:2399
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK09225
    Location:1389
    PRK09225; threonine synthase; Validated
  11. XM_006712043.2XP_006712106.1  threonine synthase-like 2 isoform X7

    See identical proteins and their annotated locations for XP_006712106.1

    UniProtKB/Swiss-Prot
    Q86YJ6
    Conserved Domains (1) summary
    cd01560
    Location:2359
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
  12. XM_011532953.2XP_011531255.1  threonine synthase-like 2 isoform X2

    Conserved Domains (2) summary
    cd01560
    Location:2408
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK09225
    Location:1397
    PRK09225; threonine synthase; Validated
  13. XM_005264402.3XP_005264459.1  threonine synthase-like 2 isoform X4

    Conserved Domains (2) summary
    cd01560
    Location:2408
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK09225
    Location:1397
    PRK09225; threonine synthase; Validated
  14. XM_006712042.3XP_006712105.1  threonine synthase-like 2 isoform X5

    Conserved Domains (2) summary
    cd01560
    Location:2408
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK09225
    Location:1397
    PRK09225; threonine synthase; Validated

RNA

  1. XR_002959311.1 RNA Sequence

  2. XR_001738821.1 RNA Sequence

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