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MRGBP MRG domain binding protein [ Homo sapiens (human) ]

Gene ID: 55257, updated on 3-May-2025
Official Symbol
MRGBPprovided by HGNC
Official Full Name
MRG domain binding proteinprovided by HGNC
Primary source
HGNC:HGNC:15866
See related
Ensembl:ENSG00000101189 MIM:611157; AllianceGenome:HGNC:15866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Eaf7; URCC4; MRG15BP; C20orf20
Summary
Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleoplasm. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in testis (RPKM 23.2), ovary (RPKM 4.6) and 24 other tissues See more
Orthologs
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See MRGBP in Genome Data Viewer
Location:
20q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62796473..62801729)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64595441..64600697)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61427825..61433081)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61407515-61407676 Neighboring gene long intergenic non-protein coding RNA 659 Neighboring gene uncharacterized LOC105372716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61424450-61425144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61426422-61426968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61435960-61436865 Neighboring gene OGFR antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13125 Neighboring gene opioid growth factor receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61446582-61447268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61447957-61448642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61449331-61450016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61450017-61450704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61454586-61455274 Neighboring gene collagen type IX alpha 3 chain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61455275-61455962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61461792-61462748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61462749-61463704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61463705-61464661 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61464662-61465617 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:61467141-61468340 Neighboring gene transcription factor like 5

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ10914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of H4/H2A histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
MRG/MORF4L-binding protein
Names
MRG-binding protein
MRG/MORF4L binding protein
up-regulated in colon cancer 4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018270.6NP_060740.1  MRG/MORF4L-binding protein

    See identical proteins and their annotated locations for NP_060740.1

    Status: VALIDATED

    Source sequence(s)
    AK001776, AL035669, BC014235, BQ445915
    Consensus CDS
    CCDS13503.1
    UniProtKB/Swiss-Prot
    A8C4L5, Q9NV56
    Related
    ENSP00000359518.3, ENST00000370487.5
    Conserved Domains (1) summary
    pfam07904
    Location:36112
    Eaf7; Chromatin modification-related protein EAF7

RNA

  1. NR_136405.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK001776, AL035669, BC014235, BM920599, BQ445915, BU902487

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62796473..62801729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    64595441..64600697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)