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MRGBP MRG domain binding protein [ Homo sapiens (human) ]

Gene ID: 55257, updated on 6-Nov-2022

Summary

Official Symbol
MRGBPprovided by HGNC
Official Full Name
MRG domain binding proteinprovided by HGNC
Primary source
HGNC:HGNC:15866
See related
Ensembl:ENSG00000101189 MIM:611157; AllianceGenome:HGNC:15866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Eaf7; URCC4; MRG15BP; C20orf20
Summary
Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 23.2), ovary (RPKM 4.6) and 24 other tissues See more
Orthologs
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Genomic context

See MRGBP in Genome Data Viewer
Location:
20q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62796473..62801729)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64595441..64600697)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61427825..61433081)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 659 Neighboring gene uncharacterized LOC105372716 Neighboring gene OGFR antisense RNA 1 Neighboring gene opioid growth factor receptor Neighboring gene collagen type IX alpha 3 chain Neighboring gene transcription factor like 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MRG/MORF4L-binding protein
Names
MRG-binding protein
MRG/MORF4L binding protein
up-regulated in colon cancer 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018270.6NP_060740.1  MRG/MORF4L-binding protein

    See identical proteins and their annotated locations for NP_060740.1

    Status: VALIDATED

    Source sequence(s)
    AK001776, AL035669, BC014235, BQ445915
    Consensus CDS
    CCDS13503.1
    UniProtKB/Swiss-Prot
    A8C4L5, Q9NV56
    Related
    ENSP00000359518.3, ENST00000370487.5
    Conserved Domains (1) summary
    pfam07904
    Location:36112
    Eaf7; Chromatin modification-related protein EAF7

RNA

  1. NR_136405.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK001776, AL035669, BC014235, BM920599, BQ445915, BU902487

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62796473..62801729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    64595441..64600697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)