U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WDR41 WD repeat domain 41 [ Homo sapiens (human) ]

Gene ID: 55255, updated on 5-Feb-2023

Summary

Official Symbol
WDR41provided by HGNC
Official Full Name
WD repeat domain 41provided by HGNC
Primary source
HGNC:HGNC:25601
See related
Ensembl:ENSG00000164253 MIM:617502; AllianceGenome:HGNC:25601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSTP048
Summary
Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of autophagy. Located in cytoplasm. Part of guanyl-nucleotide exchange factor complex. Colocalizes with Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 15.6), brain (RPKM 8.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See WDR41 in Genome Data Viewer
Location:
5q13.3-q14.1
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (77430933..77620577, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77913542..77974918, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76726758..76788141, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ZBED3 antisense RNA 1 Neighboring gene high mobility group box 1 pseudogene 35 Neighboring gene phosphodiesterase 8B Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 1 Neighboring gene uncharacterized LOC124901009 Neighboring gene ribosomal protein S2 pseudogene 24 Neighboring gene ribosomal protein L7 pseudogene 23 Neighboring gene VISTA enhancer hs262 Neighboring gene orthopedia homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10904

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 41

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018268.4NP_060738.2  WD repeat-containing protein 41

    See identical proteins and their annotated locations for NP_060738.2

    Status: VALIDATED

    Source sequence(s)
    BC040241, BG113002, BM818066, BP276774, BQ000743, CD656920
    Consensus CDS
    CCDS4038.1
    UniProtKB/Swiss-Prot
    Q9HAD4, Q9NV62
    UniProtKB/TrEMBL
    A0A0S2Z5E0
    Related
    ENSP00000296679.4, ENST00000296679.9
    Conserved Domains (2) summary
    sd00039
    Location:88131
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:38350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    77430933..77620577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543505.3XP_011541807.1  WD repeat-containing protein 41 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:7429
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:85128
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:35347
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_047417350.1XP_047273306.1  WD repeat-containing protein 41 isoform X3

  3. XM_047417349.1XP_047273305.1  WD repeat-containing protein 41 isoform X3

  4. XM_005248551.5XP_005248608.1  WD repeat-containing protein 41 isoform X4

    Related
    ENSP00000426499.1, ENST00000515253.5
    Conserved Domains (3) summary
    COG2319
    Location:34294
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:87133
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:38374
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_017009606.2XP_016865095.1  WD repeat-containing protein 41 isoform X2

  6. XM_011543507.3XP_011541809.1  WD repeat-containing protein 41 isoform X7

    Conserved Domains (3) summary
    COG2319
    Location:29254
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:87133
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:38330
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_005248552.4XP_005248609.1  WD repeat-containing protein 41 isoform X6

    Conserved Domains (3) summary
    COG2319
    Location:10357
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:88131
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:38350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_047417351.1XP_047273307.1  WD repeat-containing protein 41 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    77913542..77974918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)