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YY1AP1 YY1 associated protein 1 [ Homo sapiens (human) ]

Gene ID: 55249, updated on 17-Jun-2019

Summary

Official Symbol
YY1AP1provided by HGNC
Official Full Name
YY1 associated protein 1provided by HGNC
Primary source
HGNC:HGNC:30935
See related
Ensembl:ENSG00000163374 MIM:607860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRNG; HCCA1; HCCA2; YY1AP
Summary
The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 35.6), bone marrow (RPKM 27.3) and 25 other tissues See more
Orthologs

Genomic context

See YY1AP1 in Genome Data Viewer
Location:
1q22
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155659442..155689032, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155629233..155658823, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene gon-4 like pseudogene Neighboring gene gon-4 like pseudogene Neighboring gene small Cajal body-specific RNA 26A Neighboring gene death associated protein 3 Neighboring gene uncharacterized LOC100505728 Neighboring gene misato family member 2, pseudogene Neighboring gene gon-4 like Neighboring gene small Cajal body-specific RNA 26B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10875, FLJ13914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
YY1-associated protein 1
Names
hepatocellular carcinoma susceptibility protein
hepatocellular carcinoma-associated protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198899.1NP_001185828.1  YY1-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001185828.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks 5' two exons but has an alternate 5' segment, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (1) has a shorter N-terminus, as compared to isoform 6. Variants 1, 6 and 7 encode the same isoform 1.
    Source sequence(s)
    AK303386, BC014906, DC346197
    UniProtKB/Swiss-Prot
    Q9H869
    Conserved Domains (1) summary
    PRK10263
    Location:407615
    PRK10263; DNA translocase FtsK; Provisional
  2. NM_001198900.1NP_001185829.1  YY1-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001185829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (1) has a shorter N-terminus, as compared to isoform 6. Variants 1, 6 and 7 encode the same isoform 1.
    Source sequence(s)
    BC003500, BC009358, BC044887, DC399389
    UniProtKB/Swiss-Prot
    Q9H869
    UniProtKB/TrEMBL
    I6L9C2
    Related
    ENSP00000352134.5, ENST00000359205.9
    Conserved Domains (1) summary
    PRK10263
    Location:407615
    PRK10263; DNA translocase FtsK; Provisional
  3. NM_001198901.1NP_001185830.1  YY1-associated protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001185830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 6. Variants 3, 8 and 9 encode the same isoform 3.
    Source sequence(s)
    AY604179, BC009358, DC300265
    Consensus CDS
    CCDS1116.1
    UniProtKB/Swiss-Prot
    Q9H869
    Related
    ENSP00000357314.2, ENST00000368330.6
    Conserved Domains (1) summary
    cl26464
    Location:412678
    Atrophin-1; Atrophin-1 family
  4. NM_001198902.1NP_001185831.1  YY1-associated protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001185831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 6. Variants 3, 8 and 9 encode the same isoform 3.
    Source sequence(s)
    AF466401, BC009358, BG325066
    Consensus CDS
    CCDS1116.1
    UniProtKB/Swiss-Prot
    Q9H869
    Related
    ENSP00000316079.6, ENST00000347088.9
    Conserved Domains (1) summary
    cl26464
    Location:412678
    Atrophin-1; Atrophin-1 family
  5. NM_001198903.1NP_001185832.1  YY1-associated protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) encodes the longest isoform (6).
    Source sequence(s)
    AK297562, BC009358, BC025272, DC406177
    Consensus CDS
    CCDS55645.1
    UniProtKB/Swiss-Prot
    Q9H869
    Related
    ENSP00000357323.5, ENST00000368339.9
    Conserved Domains (1) summary
    PHA03379
    Location:550816
    PHA03379; EBNA-3A; Provisional
  6. NM_001198904.1NP_001185833.1  YY1-associated protein 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has an alternate splice site in the CDS, as compared to variant 10. The resulting isoform (7) lacks an internal segment, as compared to isoform 6.
    Source sequence(s)
    BC009358, BC025272, DC406177
    Consensus CDS
    CCDS55644.1
    UniProtKB/Swiss-Prot
    Q9H869
    Related
    ENSP00000357324.5, ENST00000368340.9
    Conserved Domains (1) summary
    PHA03379
    Location:530796
    PHA03379; EBNA-3A; Provisional
  7. NM_001198905.1NP_001185834.1  YY1-associated protein 1 isoform 8

    See identical proteins and their annotated locations for NP_001185834.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has an alternate 5' sequence, resulting in a downstream AUG start codon, and has an alternate splice site in the middle coding region, as compared to variant 10. The resulting isoform (8) has a shorter N-terminus and lacks an internal segment, as compared to isoform 6.
    Source sequence(s)
    BC008766, BC009358, DC399389
    Consensus CDS
    CCDS55643.1
    UniProtKB/Swiss-Prot
    Q9H869
    Related
    ENSP00000385390.1, ENST00000404643.5
    Conserved Domains (1) summary
    PRK10263
    Location:398606
    PRK10263; DNA translocase FtsK; Provisional
  8. NM_001198906.2NP_001185835.1  YY1-associated protein 1 isoform 9

    See identical proteins and their annotated locations for NP_001185835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) has an alternate 5' sequence and an alternate splice site in the 3' coding region, resulting in frame-shift, as compared to variant 10. The resulting isoform (9) has shorter and distinct N- and C-termini, as compared to isoform 6.
    Source sequence(s)
    AK298904, BC014906
    UniProtKB/Swiss-Prot
    Q9H869
    UniProtKB/TrEMBL
    B4DQQ0
  9. NM_018253.3NP_060723.2  YY1-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060723.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 5' sequence and an additional exon in the 5' region, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (1) has a shorter N-terminus, as compared to isoform 6. Variants 1, 6 and 7 encode the same isoform 1.
    Source sequence(s)
    BC001655, BC014906, DC399389
    UniProtKB/Swiss-Prot
    Q9H869
    Related
    ENSP00000355298.5, ENST00000361831.9
    Conserved Domains (1) summary
    PRK10263
    Location:407615
    PRK10263; DNA translocase FtsK; Provisional
  10. NM_139118.2NP_620829.1  YY1-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_620829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence and an alternate splice site in the middle coding region, as compared to variant 10. The resulting isoform (2) has a shorter and distinct N-terminus and lacks an internal segment, as compared to isoform 6.
    Source sequence(s)
    BC008766, BC014906, DC388975
    Consensus CDS
    CCDS1115.1
    UniProtKB/Swiss-Prot
    Q9H869
    Related
    ENSP00000295566.4, ENST00000295566.8
    Conserved Domains (1) summary
    PRK10263
    Location:464672
    PRK10263; DNA translocase FtsK; Provisional
  11. NM_139119.2NP_620830.1  YY1-associated protein 1 isoform 3

    See identical proteins and their annotated locations for NP_620830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 6. Variants 3, 8 and 9 encode the same isoform 3.
    Source sequence(s)
    BC014906, BC044887
    Consensus CDS
    CCDS1116.1
    UniProtKB/Swiss-Prot
    Q9H869
    UniProtKB/TrEMBL
    I6L9C2
    Related
    ENSP00000347686.4, ENST00000355499.8
    Conserved Domains (1) summary
    cl26464
    Location:412678
    Atrophin-1; Atrophin-1 family
  12. NM_139121.2NP_620832.1  YY1-associated protein 1 isoform 5

    See identical proteins and their annotated locations for NP_620832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has alternate 5' sequence and an additional exon in the 5' region, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 6.
    Source sequence(s)
    BC003500, BC009358
    UniProtKB/Swiss-Prot
    Q9H869
    Conserved Domains (1) summary
    PHA03379
    Location:346612
    PHA03379; EBNA-3A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155659442..155689032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_139120.1: Suppressed sequence

    Description
    NM_139120.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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