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OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55239, updated on 2-Mar-2021

Summary

Official Symbol
OGFOD1provided by HGNC
Official Full Name
2-oxoglutarate and iron dependent oxygenase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25585
See related
Ensembl:ENSG00000087263 MIM:615857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPA1
Expression
Ubiquitous expression in adrenal (RPKM 10.6), esophagus (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

See OGFOD1 in Genome Data Viewer
Location:
16q13
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (56451524..56479104)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56485436..56513016)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene autocrine motility factor receptor Neighboring gene nudix hydrolase 21 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene uncharacterized LOC105371283 Neighboring gene metallothionein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10826, KIAA1612

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidyl-proline 3-dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-proline dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-proline dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-proline hydroxylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-proline hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
protein hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of translational termination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of translational termination IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic stress granule IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
prolyl 3-hydroxylase OGFOD1
Names
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
TPA1, termination and polyadenylation 1, homolog
termination and polyadenylation 1 homolog
uS12 prolyl 3-hydroxylase
NP_001311286.1
NP_001311287.1
NP_001311288.1
NP_001311289.1
NP_001311290.1
NP_001311291.1
NP_001311292.1
NP_060703.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324357.2NP_001311286.1  prolyl 3-hydroxylase OGFOD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092140
  2. NM_001324358.2NP_001311287.1  prolyl 3-hydroxylase OGFOD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092140
  3. NM_001324359.1NP_001311288.1  prolyl 3-hydroxylase OGFOD1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092140
  4. NM_001324360.2NP_001311289.1  prolyl 3-hydroxylase OGFOD1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092140
  5. NM_001324361.1NP_001311290.1  prolyl 3-hydroxylase OGFOD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092140
  6. NM_001324362.1NP_001311291.1  prolyl 3-hydroxylase OGFOD1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC092140
    UniProtKB/Swiss-Prot
    Q8N543
    Conserved Domains (1) summary
    cl21496
    Location:122398
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
  7. NM_001324363.2NP_001311292.1  prolyl 3-hydroxylase OGFOD1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC092140
  8. NM_018233.4NP_060703.3  prolyl 3-hydroxylase OGFOD1 isoform 1

    See identical proteins and their annotated locations for NP_060703.3

    Status: VALIDATED

    Source sequence(s)
    AC092140, BC032919
    Consensus CDS
    CCDS10761.2
    UniProtKB/Swiss-Prot
    Q8N543
    Related
    ENSP00000457258.1, ENST00000566157.6
    Conserved Domains (2) summary
    smart00702
    Location:72238
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    cl21496
    Location:262538
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    56451524..56479104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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