U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55239, updated on 25-Nov-2025
Official Symbol
OGFOD1provided by HGNC
Official Full Name
2-oxoglutarate and iron dependent oxygenase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25585
See related
Ensembl:ENSG00000087263 MIM:615857; AllianceGenome:HGNC:25585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPA1
Summary
Enables peptidyl-proline 3-dioxygenase activity. Involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Located in cytoplasmic stress granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in adrenal (RPKM 10.6), esophagus (RPKM 9.7) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See OGFOD1 in Genome Data Viewer
Location:
16q13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56451524..56479104)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62246598..62274175)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56485436..56513016)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:56396251-56396424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56396447-56396947 Neighboring gene autocrine motility factor receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7507 Neighboring gene nudix hydrolase 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7508 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene Sharpr-MPRA regulatory region 6357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10851 Neighboring gene uncharacterized LOC105371283 Neighboring gene metallothionein 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer. Kim JH, et al. Oncotarget, 2015 Aug 14. PMID 25909288, Free PMC Article
  2. The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing. Stoehr A, et al. JCI Insight, 2019 May 21. PMID 31112528, Free PMC Article
  3. OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress. Wehner KA, et al. Mol Cell Biol, 2010 Apr. PMID 20154146, Free PMC Article
  4. OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility. Rodriguez R, et al. J Mol Cell Cardiol, 2023 Jun. PMID 37084634, Free PMC Article
  5. OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling. Saito K, et al. FEBS Lett, 2010 Aug 4. PMID 20579638

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility.
    Title: OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility.
  2. The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing.
    Title: The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing.
  3. High OGFOD1 expression is associated with papillomavirus-infected laryngeal papillomas.
    Title: OGFOD1 negatively regulated by miR-1224-5p promotes proliferation in human papillomavirus-infected laryngeal papillomas.
  4. Propose that OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer.
    Title: OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer.
  5. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
    Title: OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
  6. OGFOD1 plays an important role in ischemic cell survival and an OGFOD1 iron binding residue is required for ATPAF1 gene expression.
    Title: OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling.
  7. Data suggest that OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells subjected to arsenite-induced stress.
    Title: OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10826, KIAA1612

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-proline 3-dioxygenase activity EXP
Inferred from Experiment
more info
 PubMed 
enables peptidyl-proline 3-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-proline dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-proline dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-proline dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-proline hydroxylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-proline hydroxylation TAS
Traceable Author Statement
more info
  
involved_in protein hydroxylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translational termination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
prolyl 3-hydroxylase OGFOD1
Names
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
TPA1, termination and polyadenylation 1, homolog
termination and polyadenylation 1 homolog
uS12 prolyl 3-hydroxylase
NP_001311286.1
NP_001311287.1
NP_001311288.1
NP_001311289.1
NP_001311290.1
NP_001311291.1
NP_001311292.1
NP_060703.3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324357.2 → NP_001311286.1  prolyl 3-hydroxylase OGFOD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092140
    UniProtKB/TrEMBL
    A0A0A0MTR2
    Related
    ENSP00000547409.1, ENST00000877350.1

  2. NM_001324358.2 → NP_001311287.1  prolyl 3-hydroxylase OGFOD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092140
    UniProtKB/TrEMBL
    A0A0A0MTR2

  3. NM_001324359.1 → NP_001311288.1  prolyl 3-hydroxylase OGFOD1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092140
    UniProtKB/TrEMBL
    B4E360

  4. NM_001324360.2 → NP_001311289.1  prolyl 3-hydroxylase OGFOD1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092140
    UniProtKB/TrEMBL
    B4E360

  5. NM_001324361.1 → NP_001311290.1  prolyl 3-hydroxylase OGFOD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092140
    UniProtKB/TrEMBL
    A0A0A0MTR2
    Related
    ENSP00000594211.1, ENST00000924152.1

  6. NM_001324362.1 → NP_001311291.1  prolyl 3-hydroxylase OGFOD1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC092140
    UniProtKB/TrEMBL
    B4E360
    Conserved Domains (1) summary
    cl21496
    Location:122 → 398
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  7. NM_001324363.2 → NP_001311292.1  prolyl 3-hydroxylase OGFOD1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC092140
    UniProtKB/TrEMBL
    A0A0A0MTR2
    Related
    ENSP00000547408.1, ENST00000877349.1

  8. NM_018233.4 → NP_060703.3  prolyl 3-hydroxylase OGFOD1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092140, BC032919
    Consensus CDS
    CCDS10761.2
    UniProtKB/Swiss-Prot
    H3BUQ2, Q8N543, Q9H7U5, Q9H9J9, Q9HA87, Q9HCG0, Q9NVB6
    UniProtKB/TrEMBL
    A0A0A0MTR2
    Related
    ENSP00000457258.1, ENST00000566157.6
    Conserved Domains (2) summary
    smart00702
    Location:72 → 238
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    cl21496
    Location:262 → 538
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    56451524..56479104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    62246598..62274175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N543.1 GenPept UniProtKB/Swiss-Prot:Q8N543

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous