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SLC38A7 solute carrier family 38 member 7 [ Homo sapiens (human) ]

Gene ID: 55238, updated on 2-Oct-2018

Summary

Official Symbol
SLC38A7provided by HGNC
Official Full Name
solute carrier family 38 member 7provided by HGNC
Primary source
HGNC:HGNC:25582
See related
Ensembl:ENSG00000103042 MIM:614236; Vega:OTTHUMG00000133491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNAT7
Expression
Broad expression in testis (RPKM 12.2), brain (RPKM 4.6) and 23 other tissues See more
Orthologs

Genomic context

See SLC38A7 in Genome Data Viewer
Location:
16q21
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (58665109..58684777, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58700298..58718674, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 1 Neighboring gene small nucleolar RNA, H/ACA box 50A Neighboring gene transmembrane protein 254 pseudogene Neighboring gene glutamic-oxaloacetic transaminase 2 Neighboring gene RNA, U6 small nuclear 1155, pseudogene Neighboring gene RNY5 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Common variants at ten loci influence QT interval duration in the QTGEN Study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10815, FLJ12724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
L-asparagine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-glutamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
L-histidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-leucine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-methionine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-serine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-alanine transport IEA
Inferred from Electronic Annotation
more info
 
L-aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
L-histidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
L-serine transport IEA
Inferred from Electronic Annotation
more info
 
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
asparagine transport IEA
Inferred from Electronic Annotation
more info
 
branched-chain amino acid transport IEA
Inferred from Electronic Annotation
more info
 
glutamine transport IEA
Inferred from Electronic Annotation
more info
 
methionine transport IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
putative sodium-coupled neutral amino acid transporter 7
Names
amino acid transporter

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308384.1NP_001295313.1  putative sodium-coupled neutral amino acid transporter 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks three in-frame exons in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC010287, AI201677, BC063399
    Consensus CDS
    CCDS76883.1
    UniProtKB/TrEMBL
    H3BMC5
    Related
    ENSP00000454325.1, OTTHUMP00000250122, ENST00000564100.5, OTTHUMT00000422205
    Conserved Domains (1) summary
    cl00456
    Location:49301
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_018231.2NP_060701.1  putative sodium-coupled neutral amino acid transporter 7 isoform 1

    See identical proteins and their annotated locations for NP_060701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010287, AK001677, HY021779
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q9NVC3
    Related
    ENSP00000219320.3, OTTHUMP00000164727, ENST00000219320.8, OTTHUMT00000257389
    Conserved Domains (1) summary
    cl00456
    Location:49457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    58665109..58684777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023394.2XP_016878883.1  putative sodium-coupled neutral amino acid transporter 7 isoform X1

    UniProtKB/TrEMBL
    H3BMC5
    Conserved Domains (1) summary
    cl00456
    Location:49301
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_017023396.2XP_016878885.1  putative sodium-coupled neutral amino acid transporter 7 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:49297
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. XM_017023395.2XP_016878884.1  putative sodium-coupled neutral amino acid transporter 7 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:49338
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_017023398.2XP_016878887.1  putative sodium-coupled neutral amino acid transporter 7 isoform X4

    Conserved Domains (1) summary
    cl00456
    Location:49295
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_017023399.2XP_016878888.1  putative sodium-coupled neutral amino acid transporter 7 isoform X5

    Conserved Domains (1) summary
    cl00456
    Location:49220
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_001751951.2 RNA Sequence

  2. XR_001751952.2 RNA Sequence

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