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SLC38A7 solute carrier family 38 member 7 [ Homo sapiens (human) ]

Gene ID: 55238, updated on 15-Nov-2022

Summary

Official Symbol
SLC38A7provided by HGNC
Official Full Name
solute carrier family 38 member 7provided by HGNC
Primary source
HGNC:HGNC:25582
See related
Ensembl:ENSG00000103042 MIM:614236; AllianceGenome:HGNC:25582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNAT7
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and sodium ion transport. Predicted to be located in axon and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 12.2), brain (RPKM 4.6) and 23 other tissues See more
Orthologs
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Genomic context

See SLC38A7 in Genome Data Viewer
Location:
16q21
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (58665109..58684770, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (64457615..64477277, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58699013..58718674, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 1 Neighboring gene transmembrane protein 254-like Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 2773 Neighboring gene glutamic-oxaloacetic transaminase 2 Neighboring gene RNY5 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Common variants at ten loci influence QT interval duration in the QTGEN Study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10815, FLJ12724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-asparagine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-asparagine:sodium symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamine:sodium symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-glutamine:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables L-histidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-leucine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-methionine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-serine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in L-alanine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-histidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-serine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in asparagine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in branched-chain amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in methionine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
putative sodium-coupled neutral amino acid transporter 7
Names
Sodium-coupled neutral amino acid transporter 7
amino acid transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308384.2NP_001295313.1  putative sodium-coupled neutral amino acid transporter 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS76883.1
    UniProtKB/TrEMBL
    H3BMC5
    Related
    ENSP00000454325.1, ENST00000564100.5
    Conserved Domains (1) summary
    cl00456
    Location:49301
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_001369608.1NP_001356537.1  putative sodium-coupled neutral amino acid transporter 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q9H9I5
    Conserved Domains (1) summary
    cl00456
    Location:49457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. NM_001369609.1NP_001356538.1  putative sodium-coupled neutral amino acid transporter 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q9H9I5
    Conserved Domains (1) summary
    cl00456
    Location:49457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. NM_001369610.1NP_001356539.1  putative sodium-coupled neutral amino acid transporter 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS76883.1
    UniProtKB/TrEMBL
    H3BMC5
    Conserved Domains (1) summary
    cl00456
    Location:49301
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. NM_001369611.1NP_001356540.1  putative sodium-coupled neutral amino acid transporter 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q9H9I5
    Related
    ENSP00000454646.1, ENST00000570101.5
    Conserved Domains (1) summary
    cl00456
    Location:49457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. NM_018231.3NP_060701.1  putative sodium-coupled neutral amino acid transporter 7 isoform 1

    See identical proteins and their annotated locations for NP_060701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010287, AK001677
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q9H9I5, Q9NVC3
    Related
    ENSP00000219320.3, ENST00000219320.9
    Conserved Domains (1) summary
    cl00456
    Location:49457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. NR_161424.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010287

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    58665109..58684770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023396.2XP_016878885.1  putative sodium-coupled neutral amino acid transporter 7 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:49297
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_047434325.1XP_047290281.1  putative sodium-coupled neutral amino acid transporter 7 isoform X1

  3. XM_047434326.1XP_047290282.1  putative sodium-coupled neutral amino acid transporter 7 isoform X3

  4. XM_017023398.3XP_016878887.1  putative sodium-coupled neutral amino acid transporter 7 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:49295
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_017023399.3XP_016878888.1  putative sodium-coupled neutral amino acid transporter 7 isoform X5

    Conserved Domains (1) summary
    cl00456
    Location:49220
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. XM_047434328.1XP_047290284.1  putative sodium-coupled neutral amino acid transporter 7 isoform X5

  7. XM_047434327.1XP_047290283.1  putative sodium-coupled neutral amino acid transporter 7 isoform X4

    Related
    ENSP00000455119.1, ENST00000566598.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    64457615..64477277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)