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VRTN vertebrae development associated [ Homo sapiens (human) ]

Gene ID: 55237, updated on 4-Dec-2022

Summary

Official Symbol
VRTNprovided by HGNC
Official Full Name
vertebrae development associatedprovided by HGNC
Primary source
HGNC:HGNC:20223
See related
Ensembl:ENSG00000133980 AllianceGenome:HGNC:20223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
vertnin; C14orf115
Summary
Predicted to enable sequence-specific DNA binding activity and transposase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See VRTN in Genome Data Viewer
Location:
14q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74302993..74360008)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68556351..68567888)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74815174..74826711)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene visual system homeobox 2 Neighboring gene ATP binding cassette subfamily D member 4 Neighboring gene SUB1 pseudogene 2 Neighboring gene ribosomal protein S2 pseudogene 2 Neighboring gene synapse differentiation inducing 1 like Neighboring gene microRNA 4709 Neighboring gene NPC intracellular cholesterol transporter 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10811

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
vertnin
Names
vertebrae development homolog (pig)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018228.3NP_060698.2  vertnin

    See identical proteins and their annotated locations for NP_060698.2

    Status: VALIDATED

    Source sequence(s)
    BC053325, CX165172
    Consensus CDS
    CCDS9830.1
    UniProtKB/Swiss-Prot
    Q9H8Y1, Q9NVC7
    Related
    ENSP00000256362.4, ENST00000256362.5
    Conserved Domains (1) summary
    cl21459
    Location:274305
    HTH; Helix-turn-helix domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74302993..74360008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536911.3XP_011535213.1  vertnin isoform X1

    See identical proteins and their annotated locations for XP_011535213.1

    UniProtKB/Swiss-Prot
    Q9H8Y1, Q9NVC7
    Conserved Domains (1) summary
    cl21459
    Location:274305
    HTH; Helix-turn-helix domains

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68556351..68567888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)