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MOB1A MOB kinase activator 1A [ Homo sapiens (human) ]

Gene ID: 55233, updated on 24-Nov-2020

Summary

Official Symbol
MOB1Aprovided by HGNC
Official Full Name
MOB kinase activator 1Aprovided by HGNC
Primary source
HGNC:HGNC:16015
See related
Ensembl:ENSG00000114978 MIM:609281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B
Summary
The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in lymph node (RPKM 51.6), appendix (RPKM 43.0) and 24 other tissues See more
Orthologs

Genomic context

See MOB1A in Genome Data Viewer
Location:
2p13.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74152528..74178879, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74381394..74406006, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bolA family member 3 Neighboring gene BOLA3 divergent transcript Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Neighboring gene solute carrier family 4 member 5 Neighboring gene keratin 18 pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10788, FLJ11595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
MOB kinase activator 1A
Names
MOB1 Mps One Binder homolog A
MOB1, Mps One Binder kinase activator-like 1B
mob1 alpha
mob1 homolog 1B
mps one binder kinase activator-like 1B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317110.2NP_001304039.1  MOB kinase activator 1A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC073263, AK001650, AL122062, BC003398, BU172616, HY030276
    UniProtKB/Swiss-Prot
    Q9H8S9
    Conserved Domains (1) summary
    pfam03637
    Location:32203
    Mob1_phocein; Mob1/phocein family
  2. NM_001317111.2NP_001304040.1  MOB kinase activator 1A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC073263, AK001650, AL122062, BC003398, BI825399
    UniProtKB/Swiss-Prot
    Q9H8S9
    Conserved Domains (1) summary
    pfam03637
    Location:75246
    Mob1_phocein; Mob1/phocein family
  3. NM_001317112.2NP_001304041.1  MOB kinase activator 1A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate coding exon in the 3' end, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC073263, AK001650, AL122062, BC003398, CN426611, HY030276
    UniProtKB/Swiss-Prot
    Q9H8S9
    Conserved Domains (1) summary
    pfam03637
    Location:33138
    Mob1_phocein; Mob1/phocein family
  4. NM_018221.5NP_060691.2  MOB kinase activator 1A isoform 1

    See identical proteins and their annotated locations for NP_060691.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC073263, AK001650, AL122062, BC003398, HY030276
    Consensus CDS
    CCDS46340.1
    UniProtKB/Swiss-Prot
    Q9H8S9
    Related
    ENSP00000379364.3, ENST00000396049.5
    Conserved Domains (1) summary
    pfam03637
    Location:33204
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74152528..74178879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452973.1XP_024308741.1  MOB kinase activator 1A isoform X1

    Conserved Domains (1) summary
    pfam03637
    Location:75246
    Mob1_phocein; Mob1/phocein family
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