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PPP2R3A protein phosphatase 2 regulatory subunit B''alpha [ Homo sapiens (human) ]

Gene ID: 5523, updated on 21-Dec-2019

Summary

Official Symbol
PPP2R3Aprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B''alphaprovided by HGNC
Primary source
HGNC:HGNC:9307
See related
Ensembl:ENSG00000073711 MIM:604944
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR72; PR130; PPP2R3
Summary
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Expression
Broad expression in heart (RPKM 10.6), kidney (RPKM 9.3) and 20 other tissues See more
Orthologs

Genomic context

See PPP2R3A in Genome Data Viewer
Location:
3q22.2-q22.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (135965673..136149615)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (135684515..135866752)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374124 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6 pseudogene 1 Neighboring gene uncharacterized LOC107986135 Neighboring gene downstream neighbor of SON pseudogene Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 6 Neighboring gene MSL complex subunit 2 Neighboring gene ribosomal protein L31 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of the Protein C anticoagulant pathway.
NHGRI GWA Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
somite development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Names
PP2A subunit B isoforms B72/B130
PP2A, subunit B, R3 isoform
PR130/B''alpha1 subunit
PR72/B''alpha2 subuit
protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform
protein phosphatase 2, regulatory subunit B'', alpha
serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
NP_001177376.1
NP_002709.2
NP_871626.1
XP_006713749.1
XP_011511258.1
XP_016862276.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029234.1 RefSeqGene

    Range
    5056..187222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190447.2NP_001177376.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3

    See identical proteins and their annotated locations for NP_001177376.1

    Status: REVIEWED

    Description
    Transcript Variant: variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298059, AL389975, DB223168, DB378665
    Consensus CDS
    CCDS54642.1
    UniProtKB/Swiss-Prot
    Q06190
    Related
    ENSP00000419344.1, ENST00000490467.5
    Conserved Domains (1) summary
    pfam13499
    Location:167265
    EF-hand_7; EF-hand domain pair
  2. NM_002718.5NP_002709.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_002709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as isoform beta or isoform PR130.
    Source sequence(s)
    AK293012, AL389975, DB378665
    Consensus CDS
    CCDS3087.1
    UniProtKB/Swiss-Prot
    Q06190
    Related
    ENSP00000264977.3, ENST00000264977.8
    Conserved Domains (1) summary
    pfam13499
    Location:9031001
    EF-hand_7; EF-hand domain pair
  3. NM_181897.3NP_871626.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_871626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform alpha or isoform PR72, contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC072039, AK316258, AL389975, DB378665
    Consensus CDS
    CCDS3088.1
    UniProtKB/Swiss-Prot
    Q06190
    Related
    ENSP00000334748.2, ENST00000334546.6
    Conserved Domains (1) summary
    pfam13499
    Location:282380
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    135965673..136149615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006787.2XP_016862276.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

  2. XM_006713686.4XP_006713749.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006713749.1

    UniProtKB/Swiss-Prot
    Q06190
    Conserved Domains (1) summary
    pfam13499
    Location:9031001
    EF-hand_7; EF-hand domain pair
  3. XM_011512956.3XP_011511258.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011511258.1

    UniProtKB/Swiss-Prot
    Q06190
    Conserved Domains (1) summary
    pfam13499
    Location:9031001
    EF-hand_7; EF-hand domain pair

RNA

  1. XR_001740196.2 RNA Sequence

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