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PANK4 pantothenate kinase 4 (inactive) [ Homo sapiens (human) ]

Gene ID: 55229, updated on 8-Jul-2021

Summary

Official Symbol
PANK4provided by HGNC
Official Full Name
pantothenate kinase 4 (inactive)provided by HGNC
Primary source
HGNC:HGNC:19366
See related
Ensembl:ENSG00000157881 MIM:606162
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 4.0), heart (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See PANK4 in Genome Data Viewer
Location:
1p36.32
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (2508537..2526622, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2439976..2458035, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13804 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene phospholipase C eta 2 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene TNFRSF14 antisense RNA 1 Neighboring gene TNF receptor superfamily member 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10782, DKFZp547M242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables pantothenate kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
4'-phosphopantetheine phosphatase
Names
inactive pantothenic acid kinase 4
pantothenic acid kinase 4
NP_060686.3
XP_011540010.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018216.4NP_060686.3  4'-phosphopantetheine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AK001644, DC316156
    Consensus CDS
    CCDS42.2
    Related
    ENSP00000367727.5, ENST00000378466.9
    Conserved Domains (1) summary
    PLN02902
    Location:17771
    PLN02902; pantothenate kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    2508537..2526622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541708.3XP_011540010.2  4'-phosphopantetheine phosphatase isoform X1

    Conserved Domains (1) summary
    pfam03630
    Location:37364
    Fumble

RNA

  1. XR_241034.3 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187515.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    59727..77786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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