Format

Send to:

Choose Destination

NAT10 N-acetyltransferase 10 [ Homo sapiens (human) ]

Gene ID: 55226, updated on 4-Jul-2021

Summary

Official Symbol
NAT10provided by HGNC
Official Full Name
N-acetyltransferase 10provided by HGNC
Primary source
HGNC:HGNC:29830
See related
Ensembl:ENSG00000135372 MIM:609221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP; Kre33; NET43
Summary
The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in lymph node (RPKM 12.6), testis (RPKM 11.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NAT10 in Genome Data Viewer
Location:
11p13
Exon count:
29
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (34105629..34146908)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34127176..34168455)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1858 Neighboring gene uncharacterized LOC101929918 Neighboring gene cell cycle associated protein 1 Neighboring gene uncharacterized LOC102723539 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene MMADHC pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with NAT10 as demonstrated by proximity dependent biotinylation proteomics PubMed
gag Interaction of HIV-1 Gag with N-acetyltransferase 10 (NAT10) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Rev rev HIV-1 Rev interacting protein, N-acetyltransferase-like protein (NAT10), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10774, FLJ12179, FLJ23850, KIAA1709, DKFZp434C116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables N-acetyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
enables RNA binding HDA PubMed 
enables mRNA N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA cytidine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region HDA PubMed 
located_in membrane HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA cytidine acetyltransferase
Names
18S rRNA cytosine acetyltransferase
N-acetyltransferase 10 (GCN5-related)
N-acetyltransferase-like protein
NP_001137502.2
NP_078938.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051821.1 RefSeqGene

    Range
    5001..46348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144030.2NP_001137502.2  RNA cytidine acetyltransferase isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC090469
    Consensus CDS
    CCDS44568.1
    Related
    ENSP00000433011.2, ENST00000531159.6
    Conserved Domains (2) summary
    PLN03229
    Location:828925
    PLN03229; acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
    COG1444
    Location:19829
    TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
  2. NM_024662.3NP_078938.3  RNA cytidine acetyltransferase isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC090469
    Consensus CDS
    CCDS7889.1
    Related
    ENSP00000257829.3, ENST00000257829.8
    Conserved Domains (2) summary
    COG1444
    Location:20901
    TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
    cl27612
    Location:900997
    PLN03229; acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    34105629..34146908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center