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RAVER2 ribonucleoprotein, PTB binding 2 [ Homo sapiens (human) ]

Gene ID: 55225, updated on 26-Oct-2022

Summary

Official Symbol
RAVER2provided by HGNC
Official Full Name
ribonucleoprotein, PTB binding 2provided by HGNC
Primary source
HGNC:HGNC:25577
See related
Ensembl:ENSG00000162437 MIM:609953; AllianceGenome:HGNC:25577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine (RPKM 13.3), colon (RPKM 12.9) and 24 other tissues See more
Orthologs
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Genomic context

See RAVER2 in Genome Data Viewer
Location:
1p31.3
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (64745075..64833232)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (64623084..64711231)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (65210758..65298915)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cache domain containing 1 Neighboring gene uncharacterized LOC124904195 Neighboring gene microRNA 4794 Neighboring gene Janus kinase 1 Neighboring gene Sharpr-MPRA regulatory region 6411 Neighboring gene NDUFA4, mitochondrial complex associated pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10770, KIAA1579, DKFZp762D1011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribonucleoprotein PTB-binding 2
Names
protein raver-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366165.2NP_001353094.1  ribonucleoprotein PTB-binding 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093427, AC099678
    Consensus CDS
    CCDS90967.1
    UniProtKB/Swiss-Prot
    Q9NPV7
    Related
    ENSP00000294428.3, ENST00000294428.8
    Conserved Domains (3) summary
    cd12664
    Location:70139
    RRM1_RAVER2; RNA recognition motif 1 in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)
    cd12666
    Location:143219
    RRM2_RAVER2; RNA recognition motif 2 in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)
    cd12668
    Location:229326
    RRM3_RAVER2; RNA recognition motif 3 found in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)
  2. NM_018211.4NP_060681.2  ribonucleoprotein PTB-binding 2 isoform 2

    See identical proteins and their annotated locations for NP_060681.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB046799, AC093427, AC099678, AL359613
    Consensus CDS
    CCDS41345.1
    UniProtKB/Swiss-Prot
    Q9HCJ3
    Related
    ENSP00000360112.4, ENST00000371072.8
    Conserved Domains (3) summary
    cd12664
    Location:70139
    RRM1_RAVER2; RNA recognition motif 1 in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)
    cd12666
    Location:143219
    RRM2_RAVER2; RNA recognition motif 2 in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)
    cd12668
    Location:229326
    RRM3_RAVER2; RNA recognition motif 3 found in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    64745075..64833232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541706.3XP_011540008.1  ribonucleoprotein PTB-binding 2 isoform X1

    Conserved Domains (3) summary
    cd12664
    Location:70139
    RRM1_RAVER2; RNA recognition motif 1 in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)
    cd12666
    Location:143219
    RRM2_RAVER2; RNA recognition motif 2 in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)
    cd12668
    Location:229326
    RRM3_RAVER2; RNA recognition motif 3 found in vertebrate ribonucleoprotein PTB-binding 2 (raver-2)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    64623084..64711231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018716.1: Suppressed sequence

    Description
    NM_018716.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.