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DCUN1D2 defective in cullin neddylation 1 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 55208, updated on 17-Jun-2024

Summary

Official Symbol
DCUN1D2provided by HGNC
Official Full Name
defective in cullin neddylation 1 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20328
See related
Ensembl:ENSG00000150401 AllianceGenome:HGNC:20328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCNL2; C13orf17
Summary
Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 8.1), testis (RPKM 2.5) and 23 other tissues See more
Orthologs
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Genomic context

See DCUN1D2 in Genome Data Viewer
Location:
13q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113455819..113491563, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112714662..112750406, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114110134..114145026, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114032969-114033953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114047778-114048319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5546 Neighboring gene Sharpr-MPRA regulatory region 10007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114059695-114060489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114061607-114062292 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114064726-114065925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114071164-114072164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114072165-114073165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114075358-114076070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114076783-114077494 Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114080191-114080738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114085068-114085648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114100205-114101146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114105835-114106336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114110333-114111263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5548 Neighboring gene RNA, U1 small nuclear 16, pseudogene Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114192765-114192953 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:114195260-114196459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114200259-114201002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114206049-114206550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114236917-114237890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114237891-114238862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114240840-114241440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114251630-114252130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114267642-114268206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114268207-114268770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269335-114269898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269899-114270462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271027-114271590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271591-114272153 Neighboring gene transcription factor Dp-1 Neighboring gene uncharacterized LOC124903219 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114279174-114280373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114305936-114306560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114306561-114307185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114311832-114312332 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene G protein-coupled receptor kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10704, FLJ20092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cullin family protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in positive regulation of protein neddylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein neddylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
DCN1-like protein 2
Names
DCN1, defective in cullin neddylation 1, domain containing 2
DCUN1 domain-containing protein 2
defective in cullin neddylation protein 1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014283.2NP_001014305.1  DCN1-like protein 2

    See identical proteins and their annotated locations for NP_001014305.1

    Status: VALIDATED

    Source sequence(s)
    AK000099, AK001566, AL442125, BM836766
    Consensus CDS
    CCDS32013.1
    UniProtKB/Swiss-Prot
    Q5JSA5, Q5JSA6, Q5JSA7, Q6PH85, Q9NVJ1, Q9NXR6
    Related
    ENSP00000417706.1, ENST00000478244.6
    Conserved Domains (2) summary
    cd14412
    Location:248
    UBA_DCNL2; UBA-like domain found in DCN1-like protein 2 (DCNL2) and similar proteins
    pfam03556
    Location:136246
    Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    113455819..113491563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020647.2XP_016876136.1  DCN1-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam03556
    Location:121231
    Cullin_binding; Cullin binding
    cl21463
    Location:133
    UBA_like_SF; UBA domain-like superfamily
  2. XM_017020649.2XP_016876138.2  DCN1-like protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0C4DFQ9
    Related
    ENSP00000330629.3, ENST00000332592.7
  3. XM_017020644.2XP_016876133.1  DCN1-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam03556
    Location:121231
    Cullin_binding; Cullin binding
    cl21463
    Location:133
    UBA_like_SF; UBA domain-like superfamily
  4. XM_017020643.2XP_016876132.1  DCN1-like protein 2 isoform X1

  5. XM_017020646.3XP_016876135.1  DCN1-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam03556
    Location:121231
    Cullin_binding; Cullin binding
    cl21463
    Location:133
    UBA_like_SF; UBA domain-like superfamily
  6. XM_047430432.1XP_047286388.1  DCN1-like protein 2 isoform X2

  7. XM_047430431.1XP_047286387.1  DCN1-like protein 2 isoform X2

RNA

  1. XR_007063687.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    112714662..112750406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374656.1XP_054230631.1  DCN1-like protein 2 isoform X2

  2. XM_054374657.1XP_054230632.1  DCN1-like protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0C4DFQ9
  3. XM_054374654.1XP_054230629.1  DCN1-like protein 2 isoform X2

  4. XM_054374651.1XP_054230626.1  DCN1-like protein 2 isoform X1

  5. XM_054374655.1XP_054230630.1  DCN1-like protein 2 isoform X2

  6. XM_054374653.1XP_054230628.1  DCN1-like protein 2 isoform X2

  7. XM_054374652.1XP_054230627.1  DCN1-like protein 2 isoform X2

RNA

  1. XR_008488769.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018185.2: Suppressed sequence

    Description
    NM_018185.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.