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ARL8B ADP ribosylation factor like GTPase 8B [ Homo sapiens (human) ]

Gene ID: 55207, updated on 5-Sep-2021

Summary

Official Symbol
ARL8Bprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 8Bprovided by HGNC
Primary source
HGNC:HGNC:25564
See related
Ensembl:ENSG00000134108 MIM:616596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gie1; ARL10C
Expression
Ubiquitous expression in brain (RPKM 48.8), thyroid (RPKM 43.1) and 25 other tissues See more
Orthologs
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Genomic context

See ARL8B in Genome Data Viewer
Location:
3p26.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (5122292..5180911)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (5163977..5222596)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 10 pseudogene 1 Neighboring gene UBTF like 8 (pseudogene) Neighboring gene ER degradation enhancing alpha-mannosidase like protein 1 Neighboring gene microRNA 4790

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of ADP-ribosylation factor-like 8B (ARL8B) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10702

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation following phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antigen processing and presentation of polysaccharide antigen via MHC class II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in autophagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion regulated lysosome exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 
involved_in endosome to lysosome transport of low-density lipoprotein particle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late endosome to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lysosome localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lysosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in viral exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytolytic granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 8B
Names
ADP-ribosylation factor-like 10C
ADP-ribosylation factor-like 8B
ADP-ribosylation factor-like protein 10C
GTPase indispensable for equal segregation of chromosomes 1
novel small G protein indispensable for equal chromosome segregation 1
NP_060654.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018184.3NP_060654.1  ADP-ribosylation factor-like protein 8B

    See identical proteins and their annotated locations for NP_060654.1

    Status: VALIDATED

    Source sequence(s)
    AK001564, BC063125
    Consensus CDS
    CCDS2566.1
    UniProtKB/Swiss-Prot
    Q9NVJ2
    UniProtKB/TrEMBL
    A0A024R2D4
    Related
    ENSP00000256496.3, ENST00000256496.8
    Conserved Domains (1) summary
    cd04159
    Location:22180
    Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    5122292..5180911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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