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MAP1S microtubule associated protein 1S [ Homo sapiens (human) ]

Gene ID: 55201, updated on 11-Sep-2019

Summary

Official Symbol
MAP1Sprovided by HGNC
Official Full Name
microtubule associated protein 1Sprovided by HGNC
Primary source
HGNC:HGNC:15715
See related
Ensembl:ENSG00000130479 MIM:607573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP8; BPY2IP1; C19orf5; VCY2IP1; VCY2IP-1
Expression
Broad expression in testis (RPKM 11.7), brain (RPKM 7.0) and 25 other tissues See more
Orthologs

Genomic context

See MAP1S in Genome Data Viewer
Location:
19p13.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17719480..17734515)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17830303..17845324)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 130 Neighboring gene unc-13 homolog A Neighboring gene FCH and mu domain containing endocytic adaptor 1 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MAP1S by shRNA inhibits HIV-1 infectivity in human PBMCs PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag MAP1A and MAP1S proteins activate HIV-1 retrograde trafficking by tethering capsids to microtubules in primary human macrophages PubMed
gag MAP1A and MAP1S depletion leads to an accumulation of HIV-1 CA labelling throughout the cytoplasm, suggesting an inability both to reach the nuclear membrane and to uncoat PubMed
gag MAP1A and MAP1S proteins interact with HIV-1 CA cores in primary human macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10669, MGC133087

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT deoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagy TAS
Traceable Author Statement
more info
PubMed 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion transport along microtubule TAS
Traceable Author Statement
more info
PubMed 
nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuron projection morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of chromatin disassembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein 1S
Names
BPY2-interacting protein 1
MAP-1S
VCY2-interacting protein 1
microtubule-associated protein 8
variable charge Y chromosome 2-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308363.1NP_001295292.1  microtubule-associated protein 1S isoform 2

    See identical proteins and their annotated locations for NP_001295292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate start codon and novel 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA905204, AK294936, DB097723, DC401920
    Consensus CDS
    CCDS77262.1
    UniProtKB/Swiss-Prot
    Q66K74
    Related
    ENSP00000439243.1, ENST00000544059.2
    Conserved Domains (1) summary
    cl23716
    Location:232278
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  2. NM_018174.6NP_060644.4  microtubule-associated protein 1S isoform 1

    See identical proteins and their annotated locations for NP_060644.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA905204, BC007253, BC067115, BG771546, DB081409
    Consensus CDS
    CCDS32954.1
    UniProtKB/Swiss-Prot
    Q66K74
    Related
    ENSP00000325313.3, ENST00000324096.9
    Conserved Domains (1) summary
    cl23716
    Location:258304
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17719480..17734515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026930.2XP_016882419.1  microtubule-associated protein 1S isoform X1

  2. XM_017026931.1XP_016882420.1  microtubule-associated protein 1S isoform X2

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