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MAP1S microtubule associated protein 1S [ Homo sapiens (human) ]

Gene ID: 55201, updated on 17-Sep-2024

Summary

Official Symbol
MAP1Sprovided by HGNC
Official Full Name
microtubule associated protein 1Sprovided by HGNC
Primary source
HGNC:HGNC:15715
See related
Ensembl:ENSG00000130479 MIM:607573; AllianceGenome:HGNC:15715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP8; BPY2IP1; C19orf5; VCY2IP1; VCY2IP-1
Summary
Enables DNA binding activity and cytoskeletal protein binding activity. Involved in microtubule bundle formation; neuron projection morphogenesis; and regulation of chromatin disassembly. Located in several cellular components, including microtubule cytoskeleton; nuclear lumen; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 11.7), brain (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See MAP1S in Genome Data Viewer
Location:
19p13.11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17719480..17734513)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17853600..17868633)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17830289..17845322)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17709342-17709923 Neighboring gene ribosomal protein L21 pseudogene 130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17715726-17716630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17716631-17717535 Neighboring gene unc-13 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17797343-17798304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17798305-17799265 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17812168-17812395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17828319-17828820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14283 Neighboring gene uncharacterized LOC124904649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17849672-17850172 Neighboring gene Sharpr-MPRA regulatory region 7159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10359 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:17864444-17864964 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:17864965-17865484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14284 Neighboring gene MPRA-validated peak3395 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17877027-17877564 Neighboring gene FCH and mu domain containing endocytic adaptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17905145-17905842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17905843-17906540 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MAP1S by shRNA inhibits HIV-1 infectivity in human PBMCs PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag MAP1A and MAP1S proteins activate HIV-1 retrograde trafficking by tethering capsids to microtubules in primary human macrophages PubMed
gag MAP1A and MAP1S depletion leads to an accumulation of HIV-1 CA labelling throughout the cytoplasm, suggesting an inability both to reach the nuclear membrane and to uncoat PubMed
gag MAP1A and MAP1S proteins interact with HIV-1 CA cores in primary human macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10669, MGC133087

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables DNA nuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule anchoring at centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion transport along microtubule TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in neuron projection morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein 1S
Names
BPY2-interacting protein 1
MAP-1S
VCY2-interacting protein 1
microtubule-associated protein 8
variable charge Y chromosome 2-interacting protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308363.2NP_001295292.1  microtubule-associated protein 1S isoform 2

    See identical proteins and their annotated locations for NP_001295292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate start codon and novel 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA905204, AK294936, DB097723, DC401920
    Consensus CDS
    CCDS77262.1
    UniProtKB/TrEMBL
    A8K940
    Related
    ENSP00000439243.1, ENST00000544059.2
    Conserved Domains (1) summary
    cl23716
    Location:232278
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  2. NM_018174.6NP_060644.4  microtubule-associated protein 1S isoform 1

    See identical proteins and their annotated locations for NP_060644.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA905204, BC007253, BC067115, BG771546, DB081409
    Consensus CDS
    CCDS32954.1
    UniProtKB/Swiss-Prot
    B4DH53, Q27QB1, Q66K74, Q6NXF1, Q8N3L8, Q8N3W5, Q8NI88, Q96H94, Q96IT4, Q96SP8, Q9BRC6, Q9H928, Q9NVK7
    UniProtKB/TrEMBL
    A8K940
    Related
    ENSP00000325313.3, ENST00000324096.9
    Conserved Domains (1) summary
    cl23716
    Location:258304
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    17719480..17734513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    17853600..17868633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321358.1XP_054177333.1  microtubule-associated protein 1S isoform X1