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PPP2R2A protein phosphatase 2 regulatory subunit Balpha [ Homo sapiens (human) ]

Gene ID: 5520, updated on 29-Mar-2020

Summary

Official Symbol
PPP2R2Aprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit Balphaprovided by HGNC
Primary source
HGNC:HGNC:9304
See related
Ensembl:ENSG00000221914 MIM:604941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B55A; PR52A; PR55A; B55ALPHA; PR55alpha
Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in esophagus (RPKM 15.8), placenta (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R2A in Genome Data Viewer
Location:
8p21.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (26291508..26372680)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26149007..26230196)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379336 Neighboring gene RNA, 5S ribosomal pseudogene 258 Neighboring gene matrix metallopeptidase 12 (macrophage elastase) pseudogene Neighboring gene GATA motif-containing MPRA enhancer 260 Neighboring gene SDA1 domain containing 1 pseudogene 1 Neighboring gene BCL2 interacting protein 3 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26613, FLJ41727, MGC52248, DKFZp686N05117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
tau protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic nuclear envelope reassembly TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
peptidyl-serine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Names
protein phosphatase 2, regulatory subunit B, alpha
NP_001171062.1
NP_002708.1
XP_005273616.1
XP_005273617.1
XP_011542867.1
XP_011542868.1
XP_011542869.1
XP_011542870.1
XP_011542871.1
XP_024302954.1
XP_024302955.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177591.2NP_001171062.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2

    See identical proteins and their annotated locations for NP_001171062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC022911, AI814790, AK303981, BC041071
    Consensus CDS
    CCDS55213.1
    UniProtKB/Swiss-Prot
    P63151
    Related
    ENSP00000325074.7, ENST00000315985.7
    Conserved Domains (2) summary
    COG5170
    Location:17452
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:4189
    7WD40; WD40 repeat [structural motif]
  2. NM_002717.4NP_002708.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

    See identical proteins and their annotated locations for NP_002708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC022911, AI814790, AK314823, BC041071, DB451813
    Consensus CDS
    CCDS34867.1
    UniProtKB/Swiss-Prot
    P63151
    UniProtKB/TrEMBL
    A0A140VJT0
    Related
    ENSP00000370113.3, ENST00000380737.8
    Conserved Domains (2) summary
    COG5170
    Location:7442
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:3179
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    26291508..26372680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544567.2XP_011542869.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    See identical proteins and their annotated locations for XP_011542869.1

    Related
    ENSP00000499648.1, ENST00000665949.1
    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  2. XM_005273559.1XP_005273616.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2

    See identical proteins and their annotated locations for XP_005273616.1

    Conserved Domains (2) summary
    COG5170
    Location:7441
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:3078
    7WD40; WD40 repeat [structural motif]
  3. XM_024447186.1XP_024302954.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3

    Conserved Domains (2) summary
    COG5170
    Location:5422
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:1159
    7WD40; WD40 repeat [structural motif]
  4. XM_024447187.1XP_024302955.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  5. XM_005273560.1XP_005273617.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    See identical proteins and their annotated locations for XP_005273617.1

    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  6. XM_011544566.1XP_011542868.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    See identical proteins and their annotated locations for XP_011542868.1

    Related
    ENSP00000499441.1, ENST00000660435.1
    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  7. XM_011544568.1XP_011542870.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    See identical proteins and their annotated locations for XP_011542870.1

    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]
  8. XM_011544565.1XP_011542867.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

    See identical proteins and their annotated locations for XP_011542867.1

    Conserved Domains (3) summary
    COG5170
    Location:17451
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:4088
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:37379
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_011544569.1XP_011542871.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    See identical proteins and their annotated locations for XP_011542871.1

    Related
    ENST00000667651.1
    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2157
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_002956638.1 RNA Sequence

  2. XR_949430.3 RNA Sequence

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