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AVPR1A arginine vasopressin receptor 1A [ Homo sapiens (human) ]

Gene ID: 552, updated on 11-Jun-2021

Summary

Official Symbol
AVPR1Aprovided by HGNC
Official Full Name
arginine vasopressin receptor 1Aprovided by HGNC
Primary source
HGNC:HGNC:895
See related
Ensembl:ENSG00000166148 MIM:600821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
V1aR; AVPR1; AVPR V1a
Summary
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 29.7), endometrium (RPKM 8.7) and 7 other tissues See more
Orthologs
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Genomic context

See AVPR1A in Genome Data Viewer
Location:
12q14.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (63142759..63151201, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (63536539..63544981, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A like 6C, pseudogene Neighboring gene ribosomal L24 domain containing 1 pseudogene 5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 69 Neighboring gene DPY19L2 LCR1 recombination region 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables V1A vasopressin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding TAS
Traceable Author Statement
more info
PubMed 
enables vasopressin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vasopressin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in activation of phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
involved_in blood circulation TAS
Traceable Author Statement
more info
PubMed 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to water deprivation IEA
Inferred from Electronic Annotation
more info
 
involved_in generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
involved_in grooming behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in maternal aggressive behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in maternal behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
involved_in penile erection IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular pH reduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of systemic arterial blood pressure by vasopressin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in sperm ejaculation IEA
Inferred from Electronic Annotation
more info
 
involved_in telencephalon development IEA
Inferred from Electronic Annotation
more info
 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vasopressin V1a receptor
Names
SCCL vasopressin subtype 1a receptor
V1-vascular vasopressin receptor AVPR1A
V1a vasopressin receptor
antidiuretic hormone receptor 1A
vascular/hepatic-type arginine vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000706.5NP_000697.1  vasopressin V1a receptor

    See identical proteins and their annotated locations for NP_000697.1

    Status: REVIEWED

    Source sequence(s)
    AA533159, AC135584, AF101725
    Consensus CDS
    CCDS8965.1
    UniProtKB/Swiss-Prot
    P37288
    UniProtKB/TrEMBL
    X5D2B0
    Related
    ENSP00000299178.3, ENST00000299178.4
    Conserved Domains (2) summary
    pfam08983
    Location:372418
    DUF1856; Domain of unknown function (DUF1856)
    cd15385
    Location:52359
    7tmA_V1aR; vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    63142759..63151201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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