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CCDC198 coiled-coil domain containing 198 [ Homo sapiens (human) ]

Gene ID: 55195, updated on 13-Mar-2020

Summary

Official Symbol
CCDC198provided by HGNC
Official Full Name
coiled-coil domain containing 198provided by HGNC
Primary source
HGNC:HGNC:20189
See related
Ensembl:ENSG00000100557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf105
Expression
Biased expression in kidney (RPKM 18.4), gall bladder (RPKM 5.9) and 2 other tissues See more
Orthologs

Genomic context

See CCDC198 in Genome Data Viewer
Location:
14q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (57469300..57493981, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (57936595..57960581, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370516 Neighboring gene N-alpha-acetyltransferase 30, NatC catalytic subunit Neighboring gene uncharacterized LOC112268129 Neighboring gene uncharacterized LOC105370519 Neighboring gene uncharacterized LOC105370518 Neighboring gene solute carrier family 35 member F4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10650

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
uncharacterized protein CCDC198
Names
uncharacterized protein C14orf105

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054635.1 RefSeqGene

    Range
    5124..29681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001283056.2NP_001269985.1  uncharacterized protein CCDC198 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK001512, AK223127, AL355834, BC143567, BX470593
    Consensus CDS
    CCDS61459.1
    UniProtKB/Swiss-Prot
    Q9NVL8
    UniProtKB/TrEMBL
    B7ZL43, F5GWJ3
    Related
    ENSP00000392368.2, ENST00000422976.6
    Conserved Domains (1) summary
    pfam15398
    Location:1336
    DUF4619; Domain of unknown function (DUF4619)
  2. NM_001283057.2NP_001269986.1  uncharacterized protein CCDC198 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK001512, AK223127, AL355834, BC117405, BX470593
    Consensus CDS
    CCDS61458.1
    UniProtKB/Swiss-Prot
    Q9NVL8
    UniProtKB/TrEMBL
    E9PSE9
    Related
    ENSP00000434003.1, ENST00000534126.5
    Conserved Domains (1) summary
    pfam15398
    Location:1295
    DUF4619; Domain of unknown function (DUF4619)
  3. NM_001283058.2NP_001269987.1  uncharacterized protein CCDC198 isoform 4

    See identical proteins and their annotated locations for NP_001269987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon and uses an alternate splice site in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AK001512, AK223127, AL355834, BC143565, BX470593
    UniProtKB/Swiss-Prot
    Q9NVL8
    Conserved Domains (1) summary
    pfam15398
    Location:15207
    DUF4619; Domain of unknown function (DUF4619)
  4. NM_001283059.2NP_001269988.1  uncharacterized protein CCDC198 isoform 4

    See identical proteins and their annotated locations for NP_001269988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks an exon and uses an alternate splice site in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AK001512, AK223127, AL355834, BC143568, BX470593
    UniProtKB/Swiss-Prot
    Q9NVL8
    Conserved Domains (1) summary
    pfam15398
    Location:15207
    DUF4619; Domain of unknown function (DUF4619)
  5. NM_001283060.2NP_001269989.1  uncharacterized protein CCDC198 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains multiple differences in the UTRs and in the coding region, compared to variant 1. It initiates translation at an in-frame downstream start codon. The encoded isoform (5) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI733133, AL355834, BC028060
    UniProtKB/TrEMBL
    Q05C89
    Conserved Domains (1) summary
    pfam15398
    Location:1140
    DUF4619; Domain of unknown function (DUF4619)
  6. NM_018168.4NP_060638.2  uncharacterized protein CCDC198 isoform 2

    See identical proteins and their annotated locations for NP_060638.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK001512, AK223127, AL355834, BX470593
    Consensus CDS
    CCDS9730.1
    UniProtKB/Swiss-Prot
    Q9NVL8
    Related
    ENSP00000216445.3, ENST00000216445.7
    Conserved Domains (1) summary
    pfam15398
    Location:1296
    DUF4619; Domain of unknown function (DUF4619)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    57469300..57493981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267810.4XP_005267867.1  uncharacterized protein CCDC198 isoform X4

    Conserved Domains (1) summary
    pfam15398
    Location:1217
    DUF4619; Domain of unknown function (DUF4619)
  2. XM_005267814.1XP_005267871.1  uncharacterized protein CCDC198 isoform X7

    See identical proteins and their annotated locations for XP_005267871.1

    Conserved Domains (1) summary
    pfam15398
    Location:1169
    DUF4619; Domain of unknown function (DUF4619)
  3. XM_005267813.1XP_005267870.1  uncharacterized protein CCDC198 isoform X6

    Conserved Domains (1) summary
    pfam15398
    Location:1170
    DUF4619; Domain of unknown function (DUF4619)
  4. XM_006720189.2XP_006720252.1  uncharacterized protein CCDC198 isoform X3

    Conserved Domains (1) summary
    pfam15398
    Location:1218
    DUF4619; Domain of unknown function (DUF4619)
  5. XM_005267811.3XP_005267868.1  uncharacterized protein CCDC198 isoform X5

    Conserved Domains (1) summary
    pfam15398
    Location:15208
    DUF4619; Domain of unknown function (DUF4619)
  6. XM_006720188.2XP_006720251.1  uncharacterized protein CCDC198 isoform X2

    Conserved Domains (1) summary
    pfam15398
    Location:1226
    DUF4619; Domain of unknown function (DUF4619)
  7. XM_005267806.1XP_005267863.1  uncharacterized protein CCDC198 isoform X1

    Conserved Domains (1) summary
    pfam15398
    Location:1218
    DUF4619; Domain of unknown function (DUF4619)

RNA

  1. XR_001750401.1 RNA Sequence

  2. XR_001750400.1 RNA Sequence

  3. XR_001750402.1 RNA Sequence

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