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NUDT11 nudix hydrolase 11 [ Homo sapiens (human) ]

Gene ID: 55190, updated on 3-Jan-2019

Summary

Official Symbol
NUDT11provided by HGNC
Official Full Name
nudix hydrolase 11provided by HGNC
Primary source
HGNC:HGNC:18011
See related
Ensembl:ENSG00000196368 MIM:300528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APS1; ASP1; DIPP3b; DIPP3beta; hDIPP3beta
Summary
NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 29.1), brain (RPKM 16.8) and 4 other tissues See more
Orthologs

Genomic context

See NUDT11 in Genome Data Viewer
Location:
Xp11.22
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (51490011..51496607, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (51232863..51239459, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373204 Neighboring gene centromere protein V pseudogene Neighboring gene chromosome X open reading frame 67 Neighboring gene long intergenic non-protein coding RNA 1496 Neighboring gene tRNA-Glu (CTC) 18-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
NHGRI GWA Catalog
Multiple newly identified loci associated with prostate cancer susceptibility.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nudix (nucleoside diphosphate linked moiety X)-type motif 11 (NUDT11) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Inositol phosphate metabolism, organism-specific biosystem (from REACTOME)
    Inositol phosphate metabolism, organism-specific biosystemInositol phosphates (IPs) are molecules involves in signalling processes in eukaryotes. myo-Inositol consists of a six-carbon cyclic alcohol with an axial 2-hydroxy and five equatorial hydroxyls. M...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Synthesis of pyrophosphates in the cytosol, organism-specific biosystem (from REACTOME)
    Synthesis of pyrophosphates in the cytosol, organism-specific biosystemInositol phosphates such as IP4, IP5 and IP6 are converted to an even wider variety of IPs including the di- and triphospho inositol phosphates, also known as pyrophosphates (Irvine & Schell 2001, Al...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10628

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bis(5'-adenosyl)-hexaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bis(5'-adenosyl)-pentaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diphosphoinositol-polyphosphate diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diphosphoinositol-polyphosphate diphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
endopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol bisdiphosphate tetrakisphosphate diphosphatase activity TAS
Traceable Author Statement
more info
 
inositol diphosphate pentakisphosphate diphosphatase activity TAS
Traceable Author Statement
more info
 
inositol diphosphate tetrakisphosphate diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diadenosine hexaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diadenosine pentaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diphosphoinositol polyphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
diphosphoinositol polyphosphate phosphohydrolase 3-beta
Names
DIPP-3-beta
DIPP3-beta
diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta
diadenosine hexaphosphate hydrolase (AMP-forming)
diphosphoinositol polyphosphate phosphohydrolase 3, beta
hAps1
nucleoside diphosphate-linked moiety X motif 11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
nudix motif 11
NP_060629.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018159.4NP_060629.2  diphosphoinositol polyphosphate phosphohydrolase 3-beta

    See identical proteins and their annotated locations for NP_060629.2

    Status: VALIDATED

    Source sequence(s)
    AL158055, BC009942, BX419815
    Consensus CDS
    CCDS43952.1
    UniProtKB/Swiss-Prot
    Q96G61
    Related
    ENSP00000365160.3, ENST00000375992.3
    Conserved Domains (1) summary
    cd04666
    Location:18137
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    51490011..51496607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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