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FAIM Fas apoptotic inhibitory molecule [ Homo sapiens (human) ]

Gene ID: 55179, updated on 21-Dec-2019

Summary

Official Symbol
FAIMprovided by HGNC
Official Full Name
Fas apoptotic inhibitory moleculeprovided by HGNC
Primary source
HGNC:HGNC:18703
See related
Ensembl:ENSG00000158234 MIM:617535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAIM1
Summary
The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Expression
Ubiquitous expression in fat (RPKM 4.9), thyroid (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See FAIM in Genome Data Viewer
Location:
3q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (138608099..138633376)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138327542..138352218)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene extended synaptotagmin 3 Neighboring gene centrosomal protein 70 Neighboring gene peptidylprolyl isomerase A pseudogene 72 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fas apoptotic inhibitory molecule 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029625.1 RefSeqGene

    Range
    5072..29677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033030.2NP_001028202.1  fas apoptotic inhibitory molecule 1 isoform a

    See identical proteins and their annotated locations for NP_001028202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK125477, BC012478, BM469375
    Consensus CDS
    CCDS33864.1
    UniProtKB/Swiss-Prot
    Q9NVQ4
    Related
    ENSP00000342805.4, ENST00000338446.8
    Conserved Domains (1) summary
    pfam06905
    Location:37208
    FAIM1; Fas apoptotic inhibitory molecule (FAIM1)
  2. NM_001033031.2NP_001028203.1  fas apoptotic inhibitory molecule 1 isoform b

    See identical proteins and their annotated locations for NP_001028203.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK125477, BC012478, BQ638715
    Consensus CDS
    CCDS33865.1
    UniProtKB/Swiss-Prot
    Q9NVQ4
    Related
    ENSP00000353775.3, ENST00000360570.7
    Conserved Domains (1) summary
    pfam06905
    Location:25196
    FAIM1; Fas apoptotic inhibitory molecule (FAIM1)
  3. NM_001033032.2NP_001028204.1  fas apoptotic inhibitory molecule 1 isoform c

    See identical proteins and their annotated locations for NP_001028204.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AK125477, BC012478
    Consensus CDS
    CCDS3103.1
    UniProtKB/Swiss-Prot
    Q9NVQ4
    Related
    ENSP00000376755.2, ENST00000393035.6
    Conserved Domains (1) summary
    pfam06905
    Location:2176
    FAIM1; Fas apoptotic inhibitory molecule (FAIM1)
  4. NM_018147.4NP_060617.1  fas apoptotic inhibitory molecule 1 isoform c

    See identical proteins and their annotated locations for NP_060617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC020890, AK001444, BC012478
    Consensus CDS
    CCDS3103.1
    UniProtKB/Swiss-Prot
    Q9NVQ4
    Related
    ENSP00000376754.2, ENST00000393034.6
    Conserved Domains (1) summary
    pfam06905
    Location:2176
    FAIM1; Fas apoptotic inhibitory molecule (FAIM1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    138608099..138633376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512950.3XP_011511252.1  fas apoptotic inhibitory molecule 1 isoform X1

    Conserved Domains (1) summary
    pfam06905
    Location:57228
    FAIM1; Fas apoptotic inhibitory molecule (FAIM1)
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