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SEC61A2 SEC61 translocon subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 55176, updated on 1-Aug-2020

Summary

Official Symbol
SEC61A2provided by HGNC
Official Full Name
SEC61 translocon subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:17702
See related
Ensembl:ENSG00000065665 MIM:618271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Expression
Broad expression in brain (RPKM 12.8), testis (RPKM 10.0) and 24 other tissues See more
Orthologs

Genomic context

See SEC61A2 in Genome Data Viewer
Location:
10p14
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (12129641..12169958)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (12171640..12211957)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376416 Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene RNA, U6 small nuclear 88, pseudogene Neighboring gene microRNA 548ak Neighboring gene nudix hydrolase 5 Neighboring gene cell division cycle 123 Neighboring gene FOXA motif-containing MPRA enhancer 241 Neighboring gene RNA, 7SL, cytoplasmic 198, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DHTKD1

Homology

Clone Names

  • FLJ10578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
posttranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein transport protein Sec61 subunit alpha isoform 2
Names
SEC61 translocon alpha 2 subunit
Sec61 alpha 2 subunit
Sec61 alpha form 2
protein transport protein Sec61 subunit alpha
sec61 alpha-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142627.2NP_001136099.1  protein transport protein Sec61 subunit alpha isoform 2 isoform c

    See identical proteins and their annotated locations for NP_001136099.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c) with a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK022640, AK057532, AK292295, BC026179, BP212860
    Consensus CDS
    CCDS44358.1
    UniProtKB/Swiss-Prot
    Q9H9S3
    UniProtKB/TrEMBL
    B3KQ68, Q8TC24
    Related
    ENSP00000302048.8, ENST00000304267.12
    Conserved Domains (1) summary
    PTZ00219
    Location:1415
    PTZ00219; Sec61 alpha subunit; Provisional
  2. NM_001142628.1NP_001136100.1  protein transport protein Sec61 subunit alpha isoform 2 isoform b

    See identical proteins and their annotated locations for NP_001136100.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. Isoform b is shorter, compared to isoform a.
    Source sequence(s)
    AC073160, AK301841, BC026179, BP212860, BX645143
    Consensus CDS
    CCDS44359.1
    UniProtKB/Swiss-Prot
    Q9H9S3
    UniProtKB/TrEMBL
    Q8TC24
    Related
    ENSP00000368319.3, ENST00000379033.7
    Conserved Domains (1) summary
    PTZ00219
    Location:1447
    PTZ00219; Sec61 alpha subunit; Provisional
  3. NM_018144.4NP_060614.2  protein transport protein Sec61 subunit alpha isoform 2 isoform a

    See identical proteins and their annotated locations for NP_060614.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC073160, AK292295, BC026179, BP212860, BX645143
    Consensus CDS
    CCDS7088.1
    UniProtKB/Swiss-Prot
    Q9H9S3
    UniProtKB/TrEMBL
    Q8TC24
    Related
    ENSP00000298428.9, ENST00000298428.14
    Conserved Domains (1) summary
    PTZ00219
    Location:1469
    PTZ00219; Sec61 alpha subunit; Provisional

RNA

  1. NR_024576.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057532, BC026179, BP212860
    Related
    ENST00000475268.5
  2. NR_024577.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057532, BC026179, BP212860
    Related
    ENST00000495368.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    12129641..12169958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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