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INTS10 integrator complex subunit 10 [ Homo sapiens (human) ]

Gene ID: 55174, updated on 4-Dec-2022

Summary

Official Symbol
INTS10provided by HGNC
Official Full Name
integrator complex subunit 10provided by HGNC
Primary source
HGNC:HGNC:25548
See related
Ensembl:ENSG00000104613 MIM:611353; AllianceGenome:HGNC:25548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT10; C8orf35
Summary
INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 19.2), prostate (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

See INTS10 in Genome Data Viewer
Location:
8p21.3
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (19817416..19852067)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (20082438..20117090)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (19674927..19709578)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene uncharacterized LOC124901899 Neighboring gene uncharacterized LOC107986920 Neighboring gene uncharacterized LOC124901901 Neighboring gene uncharacterized LOC105379309

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
EBI GWAS Catalog
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription elongation by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA processing IC
Inferred by Curator
more info
PubMed 
involved_in snRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of integrator complex IC
Inferred by Curator
more info
PubMed 
part_of integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrator complex subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353505.2NP_001340434.1  integrator complex subunit 10 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC107964
  2. NM_001353506.2NP_001340435.1  integrator complex subunit 10 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC107964
  3. NM_001353507.2NP_001340436.1  integrator complex subunit 10 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC107964
  4. NM_001353508.2NP_001340437.1  integrator complex subunit 10 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC107964
  5. NM_001353509.2NP_001340438.1  integrator complex subunit 10 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC107964
  6. NM_001353510.2NP_001340439.1  integrator complex subunit 10 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC107964
  7. NM_001353511.2NP_001340440.1  integrator complex subunit 10 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC107964
  8. NM_001353512.2NP_001340441.1  integrator complex subunit 10 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC107964
  9. NM_001353513.2NP_001340442.1  integrator complex subunit 10 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC107964
  10. NM_001353514.2NP_001340443.1  integrator complex subunit 10 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC107964
  11. NM_001353515.2NP_001340444.1  integrator complex subunit 10 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC107964
  12. NM_001353516.2NP_001340445.1  integrator complex subunit 10 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC107964
  13. NM_001353517.2NP_001340446.1  integrator complex subunit 10 isoform n

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), along with variants 15 and 16, encodes isoform n.
    Source sequence(s)
    AC107964
  14. NM_001353518.2NP_001340447.1  integrator complex subunit 10 isoform n

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), along with variants 14 and 16, encodes isoform n.
    Source sequence(s)
    AC107964
  15. NM_001353519.2NP_001340448.1  integrator complex subunit 10 isoform n

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), along with variants 14 and 15, encodes isoform n.
    Source sequence(s)
    AC107964
  16. NM_001353520.2NP_001340449.1  integrator complex subunit 10 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC107964
  17. NM_001353521.2NP_001340450.1  integrator complex subunit 10 isoform p

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform p.
    Source sequence(s)
    AC107964
  18. NM_001353522.2NP_001340451.1  integrator complex subunit 10 isoform p

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform p.
    Source sequence(s)
    AC107964
  19. NM_018142.4NP_060612.2  integrator complex subunit 10 isoform g

    See identical proteins and their annotated locations for NP_060612.2

    Status: VALIDATED

    Source sequence(s)
    AC107964
    Consensus CDS
    CCDS6011.2
    UniProtKB/Swiss-Prot
    Q9H3W8, Q9NVR2
    Related
    ENSP00000381064.3, ENST00000397977.8

RNA

  1. NR_148451.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964
  2. NR_148452.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964
  3. NR_148453.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964
  4. NR_148454.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964
  5. NR_148455.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964
  6. NR_148456.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964
  7. NR_148457.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964
  8. NR_148458.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107964

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    19817416..19852067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421928.1XP_047277884.1  integrator complex subunit 10 isoform X1

  2. XM_047421929.1XP_047277885.1  integrator complex subunit 10 isoform X2

  3. XM_047421930.1XP_047277886.1  integrator complex subunit 10 isoform X3

  4. XM_017013607.2XP_016869096.1  integrator complex subunit 10 isoform X4

  5. XM_047421931.1XP_047277887.1  integrator complex subunit 10 isoform X5

RNA

  1. XR_007060743.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    20082438..20117090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)