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PRMT6 protein arginine methyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 55170, updated on 22-Jan-2023


Official Symbol
PRMT6provided by HGNC
Official Full Name
protein arginine methyltransferase 6provided by HGNC
Primary source
See related
Ensembl:ENSG00000198890 MIM:608274; AllianceGenome:HGNC:18241
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
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Genomic context

See PRMT6 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (107056674..107059294)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (107094127..107096747)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (107599296..107601916)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378888 Neighboring gene long intergenic non-protein coding RNA 1661 Neighboring gene nudE neurodevelopment protein 1 pseudogene 1 Neighboring gene netrin G1 Neighboring gene NDUFA4 pseudogene 1

Genomic regions, transcripts, and products


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
EBI GWAS Catalog
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
EBI GWAS Catalog
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
EBI GWAS Catalog
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
EBI GWAS Catalog
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 Env (gp160) protein methylation mediated by PRMT6 is required to maintain optimal HIV-1 infectivity PubMed
Rev rev PRMT6 mutant V86K/D88A fails to methylate HIV-1 Rev. PRMT6 is automethylated at position R35, which regulates its stability and is necessary for its HIV-1 restriction activity PubMed
rev Arginine 38 methylation of HIV-1 Rev by PRMT6 reduces RRE binding and diminishes export of viral RNA to the cytoplasm PubMed
Tat tat HIV-1 Tat nucleolar retention (dependent on Tat residues 49-57) is inhibited by PRMT6 PubMed
tat The termini (residues 1-84 and 321-375) of PRMT6 and the activation domain (residues 1-37) of HIV-1 Tat are required for the interaction between PRMT6 and Tat PubMed
tat PRMT6 increases the steady-state level of HIV-1 Tat in the cell and the basic domain (residues 49-57) of Tat is required for the PRMT6-mediated increase of Tat steady-state levels PubMed
tat HIV-1 Tat is methylated at positions Arg52 and Arg53 by PRMT6. Arginine methylation of Tat negatively affects Tat-TAR-cyclin T1 ternary complex formation and diminishes cyclin T1-dependent Tat transcriptional activation PubMed
tat HIV-1 Tat specifically interacts with and is methylated by PRMT6 within cells; overexpression of wild-type PRMT6 decreases Tat transactivation of an HIV-1 long terminal repeat luciferase reporter plasmid in a dose-dependent manner PubMed
nucleocapsid gag HIV-1 NC is methylated at positions Arg10 and Arg32 by PRMT6 both in vitro and in vivo, and methylated NC is less able than wild-type to promote RNA annealing and participates in the initiation of reverse transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ10559, FLJ51477

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
located_in nucleoplasm TAS
Traceable Author Statement
more info
located_in nucleus IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
protein arginine N-methyltransferase 6
HMT1 hnRNP methyltransferase-like 6
heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
histone-arginine N-methyltransferase PRMT6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018137.3NP_060607.2  protein arginine N-methyltransferase 6

    See identical proteins and their annotated locations for NP_060607.2

    Status: VALIDATED

    Source sequence(s)
    AI754232, AY043278, DA073209
    Consensus CDS
    Q96LA8, Q9NVR8
    ENSP00000359095.1, ENST00000370078.2
    Conserved Domains (1) summary
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060925.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)