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PRMT6 protein arginine methyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 55170, updated on 27-Nov-2024

Summary

Official Symbol
PRMT6provided by HGNC
Official Full Name
protein arginine methyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:18241
See related
Ensembl:ENSG00000198890 MIM:608274; AllianceGenome:HGNC:18241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRMT1L6
Summary
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
Orthologs
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Genomic context

See PRMT6 in Genome Data Viewer
Location:
1p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (107056674..107059294)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (107094127..107096747)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (107599296..107601916)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378888 Neighboring gene long intergenic non-protein coding RNA 1661 Neighboring gene nudE neurodevelopment protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:107683301-107683832 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1130 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:107707080-107708279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1131 Neighboring gene netrin G1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:107963104-107963605 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:107974475-107975331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1419 Neighboring gene NDUFA4 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
EBI GWAS Catalog
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
EBI GWAS Catalog
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
EBI GWAS Catalog
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
EBI GWAS Catalog
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 Env (gp160) protein methylation mediated by PRMT6 is required to maintain optimal HIV-1 infectivity PubMed
Rev rev PRMT6 mutant V86K/D88A fails to methylate HIV-1 Rev. PRMT6 is automethylated at position R35, which regulates its stability and is necessary for its HIV-1 restriction activity PubMed
rev Arginine 38 methylation of HIV-1 Rev by PRMT6 reduces RRE binding and diminishes export of viral RNA to the cytoplasm PubMed
Tat tat HIV-1 Tat nucleolar retention (dependent on Tat residues 49-57) is inhibited by PRMT6 PubMed
tat The termini (residues 1-84 and 321-375) of PRMT6 and the activation domain (residues 1-37) of HIV-1 Tat are required for the interaction between PRMT6 and Tat PubMed
tat PRMT6 increases the steady-state level of HIV-1 Tat in the cell and the basic domain (residues 49-57) of Tat is required for the PRMT6-mediated increase of Tat steady-state levels PubMed
tat HIV-1 Tat is methylated at positions Arg52 and Arg53 by PRMT6. Arginine methylation of Tat negatively affects Tat-TAR-cyclin T1 ternary complex formation and diminishes cyclin T1-dependent Tat transcriptional activation PubMed
tat HIV-1 Tat specifically interacts with and is methylated by PRMT6 within cells; overexpression of wild-type PRMT6 decreases Tat transactivation of an HIV-1 long terminal repeat luciferase reporter plasmid in a dose-dependent manner PubMed
nucleocapsid gag HIV-1 NC is methylated at positions Arg10 and Arg32 by PRMT6 both in vitro and in vivo, and methylated NC is less able than wild-type to promote RNA annealing and participates in the initiation of reverse transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10559, FLJ51477

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AQ104 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AR3 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3 methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
enables histone H3 methyltransferase activity TAS
Traceable Author Statement
more info
 
enables histone H3K37 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K56 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3R17 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3R2 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3R26 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3R8 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K12 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4R3 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-arginine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-arginine omega-N monomethyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein arginine N-methyltransferase 6
Names
HMT1 hnRNP methyltransferase-like 6
heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
histone-arginine N-methyltransferase PRMT6
NP_060607.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018137.3NP_060607.2  protein arginine N-methyltransferase 6

    See identical proteins and their annotated locations for NP_060607.2

    Status: VALIDATED

    Source sequence(s)
    AI754232, AY043278, DA073209
    Consensus CDS
    CCDS41360.2
    UniProtKB/Swiss-Prot
    A3KME1, B4DID8, Q5T5Y5, Q6DKI4, Q96LA8, Q9NVR8
    UniProtKB/TrEMBL
    A0A3B3ITK4
    Related
    ENSP00000359095.1, ENST00000370078.2
    Conserved Domains (1) summary
    cl17173
    Location:67200
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    107056674..107059294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    107094127..107096747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)